Anti-Osteoprotegerin antibody produced in goat

The antibody will neutralize the biological activity of recombinant human OPG. The antibody shows 50% cross-reactivity with recombinant mouse OPG.

recombinant human OPG expressed in the insect cell line Sf 21.

Osteoprotegerin (OPG) secreted by osteoblasts and osteogenis stromal stem cells belongs to the TNF receptor superfamily. OPG is expressed in bone marrow, osteoblasts, heart, lung, kidney, thymus, B lymphocytes, chondrocytes and smooth muscle cells. The ratio of OPG and receptor activator of NF-κB Ligand (RANKL) is crucial for determining the bone mass. Excess levels of OPG lead to osteopetrosis while deficiency results in osteoporosis.

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

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