O7753
草酰乙酸
powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥97% (HPLC)
别名:
2-氧代丁二酸, 丁酮二酸, 氧代丁二酸, 草醋酸
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线性分子式:
HOOCCH2COCOOH
化学文摘社编号:
分子量:
132.07
UNSPSC Code:
12352204
NACRES:
NA.75
PubChem Substance ID:
EC Number:
206-329-8
Beilstein/REAXYS Number:
1705475
MDL number:
产品名称
草酰乙酸, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥97% (HPLC)
Quality Level
InChI key
KHPXUQMNIQBQEV-UHFFFAOYSA-N
InChI
1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9)
SMILES string
OC(=O)CC(=O)C(O)=O
biological source
synthetic (organic)
product line
BioReagent
assay
≥97% (HPLC)
form
powder
technique(s)
cell culture | insect: suitable
cell culture | mammalian: suitable
solubility
H2O: 100 mg/mL
storage temp.
−20°C
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Application
草酰乙酸已用于评价对肌萎缩性侧索硬化症（ALS）模型超氧化物歧化酶1 (SOD1) G93A小鼠神经肌肉功能和寿命的影响。它还被用作杜氏改良Eagles培养基（DMEM）的补充剂，用于培养鸡成纤维细胞（DF-1）和化学永生化来角雄性肝癌（LMH）细胞，以进行功能验证实验。
Biochem/physiol Actions
草酰乙酸在中枢代谢中起重要作用。它可抑制琥珀酸脱氢酶，是线粒体代谢的一种关键调节剂。
General description
草酰乙酸是一种二羧酸，存在于人体的每个细胞中。它是三羧酸（TCA）循环和糖异生的代谢中间体。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Brian D Fink et al.
The Journal of biological chemistry, 293(51), 19932-19941 (2018-11-06)
We recently reported a previously unrecognized mitochondrial respiratory phenomenon. When [ADP] was held constant ("clamped") at sequentially increasing concentrations in succinate-energized muscle mitochondria in the absence of rotenone (commonly used to block complex I), we observed a biphasic, increasing then
Zhitao Wang et al.
Viruses, 13(6) (2021-07-03)
Gallid alpha-herpesvirus 1, also known as avian infectious laryngotracheitis virus (ILTV), continues to cause huge economic losses to the poultry industry worldwide. Similar to that of other herpesvirus-encoded proteins, the expression of viral genes encoded by ILTV is regulated by
Alexander Zlotnik et al.
Anesthesiology, 116(1), 73-83 (2011-12-02)
Decreasing blood glutamate concentrations after traumatic brain injury accelerates brain-to-blood glutamate efflux, leading to improved neurologic outcomes. The authors hypothesize that treatment with blood glutamate scavengers should reduce neuronal cell loss, whereas administration of glutamate should worsen outcomes. The authors
Lee Hua Long et al.
Biochemical and biophysical research communications, 417(1), 446-450 (2011-12-15)
Several phenolic compounds as well as ascorbate can oxidise in certain cell culture media (especially Dulbecco's modified Eagle's medium (DMEM)) to generate hydrogen peroxide. Addition of oxaloacetate decreased the levels of H(2)O(2) detected and the oxaloacetate was depleted. Oxaloacetate was
L T Wong et al.
Pediatric research, 20(3), 274-279 (1986-03-01)
An infant with the acute neonatal form of pyruvate carboxylase deficiency (cross-reacting material negative) presented with severe intractable lactic acidosis within 4 h after birth. He also had hyperammonemia, hypercitrullinemia, and hyperlysinemia. Plasma glutamine was not elevated. He had a
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