O8014
Org 27569
≥98% (HPLC)
别名:
5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide
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关于此项目
经验公式（希尔记法）:
C24H28ClN3O
化学文摘社编号:
分子量:
409.95
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
278-169-7
MDL number:
InChI key
AHFZDNYNXFMRFQ-UHFFFAOYSA-N
InChI
1S/C24H28ClN3O/c1-2-20-21-16-18(25)8-11-22(21)27-23(20)24(29)26-13-12-17-6-9-19(10-7-17)28-14-4-3-5-15-28/h6-11,16,27H,2-5,12-15H2,1H3,(H,26,29)
SMILES string
CCc1c([nH]c2ccc(Cl)cc12)C(=O)NCCc3ccc(cc3)N4CCCCC4
assay
≥98% (HPLC)
form
powder
color
white
solubility
H2O: <2 mg/mL, DMSO: >5 mg/mL
storage temp.
2-8°C
Biochem/physiol Actions
Org 27569 is an allosteric modulator of CB1 cannabinoid receptor.
Org 27569 is an allosteric modulator of CB1 cannabinoid receptor. It significantly increases the binding of CB1 receptor agonist [3H]-CP 55,940 (pKB = 5.67) and causes a significant decrease in specific binding of CB1 receptor inverse agonist SR141716A (Rimonabant; pKB = 5.95); in the reporter gene assay behaves as insurmountable CP 55,940 antagonist; pKB = 7.57 at CB1 receptors in mouse vas deferens
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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