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O9126

Oxotremorine sesquifumarate salt

Name: Oxotremorine sesquifumarate salt
Brand: SIGMA

≥98% (HPLC), solid

别名:

1-(4-[1-Pyrrolidinyl]-2-butynyl)-2-pyrrolidinone, 1-(4-[1-Pyrrolidinyl]2-butynyl)-2-pyrrolidinone

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关于此项目

经验公式（希尔记法）:

C₁₂H₁₈N₂O · 1.5C₄H₄O₄ · xH₂O

化学文摘社编号:

17360-35-9

分子量:

380.39 (anhydrous basis)

NACRES:

NA.77

PubChem Substance ID:

24278614

UNSPSC Code:

12352200

EC Number:

241-388-3

MDL number:

MFCD00013163

Assay:

≥98% (HPLC)

Form:

solid

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属性

assay

≥98% (HPLC)

form

solid

mp

102-105 °C (lit.)

solubility

H₂O: >10 mg/mL

storage temp.

2-8°C

SMILES string

[H]\C(=C(\[H])C(O)=O)C(O)=O.[H]\C(=C(\[H])C(O)=O)C(O)=O.[H]\C(=C(\[H])C(O)=O)C(O)=O.O=C1CCCN1CC#CCN2CCCC2.O=C3CCCN3CC#CCN4CCCC4

InChI

1S/2C12H18N2O.3C4H4O4/c2*15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13;3*5-3(6)1-2-4(7)8/h2*1-2,5-11H2;3*1-2H,(H,5,6)(H,7,8)/b;;3*2-1+

InChI key

WLYYOFJEBGHKEC-VQYXCCSOSA-N

Gene Information

human ... CHRM2(1129)

说明

Biochem/physiol Actions

Oxotremorine sesquifumarate salt is a muscarinic acetylcholine receptor agonist with preference for the M₂ receptor.

pictograms

GHS06

signalword

Danger

hcodes

H300 + H310 + H330

pcodes

P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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M1 acetylcholine receptor stimulation increases the extracellular concentrations of glutamate and GABA in the medial prefrontal cortex of the rat.

B Sanz et al.

Neurochemical research, 22(3), 281-286 (1997-03-01)

The present study was undertaken to examine the effects of different muscarinic receptor agonists on glutamate and GABA concentrations in the medial prefrontal cortex of the rat. In vivo perfusions were made in the conscious rat using a concentric push-pull

Pretest beta-endorphin and epinephrine, but not oxotremorine, reverse retrograde interference of a conditioned emotional response in mice.

I Izquierdo et al.

Pharmacology, biochemistry, and behavior, 33(3), 545-548 (1989-07-01)

CD-1 mice were trained in a classically conditioned emotional response paradigm and tested 24 hr later. Exposure to an open field 0 or 1, but not 3 hr after training retroactively interfered with retention of the conditioned emotional response. The

Cholinergic effects on fear conditioning II: nicotinic and muscarinic modulations of atropine-induced disruption of the degraded contingency effect.

Sebastien Carnicella et al.

Psychopharmacology, 178(4), 533-541 (2005-02-08)

In a companion study (Carnicella et al., 2005), we showed that the muscarinic antagonist atropine, when administered after extensive training during both conditioning and testing, affected neither cued nor contextual fear memories when both of them did not compete for

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全球贸易项目编号

货号	GTIN
O9126-100MG	04061832083421
O9126-500MG	04061834248781
O9126-1G	04061825982588