O9389
奥替普拉
≥98% (HPLC), powder
别名:
1,2-二硫杂环戊烷-3-硫酮, BRN 0978110, CCRIS 4048, NSC 347901, RP 35972
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关于此项目
经验公式（希尔记法）:
C8H6N2S3
化学文摘社编号:
分子量:
226.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
264-736-6
MDL number:
InChI
1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3
InChI key
CKNAQFVBEHDJQV-UHFFFAOYSA-N
SMILES string
CC1=C(SSC1=S)c2cnccn2
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
red
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
Quality Level
General description
Oltipraz是一种二硫醇衍生物，是二硫代硫酮类有机硫化合物的成员。它具有抗肿瘤，抗氧化，抗炎和放射防护的特性。 可以抵抗多种致癌物。Oltipraz可以用作抗血吸虫药。
Biochem/physiol Actions
Oltipraz 是 Nrf2 的激活剂。
Oltipraz是Nrf2的激活剂。 Nrf2（NF-E2相关因子2）是一种转录因子，可与抗氧化反应元件(ARE) 结合并激活这些基因。 Oltipraz可激活Nrf2，随后提高编码抗氧化剂和多药耐药相关蛋白的解毒基因的表达，以介导其化学预防功效。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Yoko Yagishita et al.
Antioxidants (Basel, Switzerland), 9(8) (2020-08-14)
The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) plays a critical role in the maintenance of cellular redox and metabolic homeostasis, as well as the regulation of inflammation and cellular detoxication pathways. The contribution of the NRF2
Min Kyung Kang et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 12(1), 1-16 (2009-05-28)
To evaluate the pharmacokinetic interaction between oltipraz and silymarin after intravenous and oral administration of both drugs to male Sprague-Dawley rats. Oltipraz (single doses of 10 and 30 mg/kg for intravenous and oral administration, respectively), silymarin (single doses of 50
Z Yu et al.
Diabetologia, 54(4), 922-934 (2010-12-17)
We investigated whether oltipraz, a nuclear respiratory factor 2 alpha subunit (NRF2) activator, improves insulin sensitivity and prevents the development of obesity in mice. C57BL/6J mice were fed with a low-fat diet (10% of energy as fat), a high-fat diet
Varsha Rani et al.
Chemico-biological interactions, 295, 84-92 (2017-10-13)
Dimethylnitrosamine (DMN) is a potent hepatotoxic, carcinogenic and mutagenic compound. It induces massive liver cell necrosis and death in experimental animals. Several drugs have been tested in the past for their protective behavior against DMN toxicity. However, it is for
Song Hwa Choi et al.
Expert opinion on drug metabolism & toxicology, 6(2), 213-224 (2010-01-26)
Comprehensive studies indicate that oltipraz exerts cancer chemopreventive effects. Oltipraz has other therapeutic potentials, which include anti-fibrotic effect, inhibition of insulin resistance, mitochondrial protection and cytoprotective effect against oxidative stress. Although antioxidant mechanisms may account for its cancer chemopreventive effect
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