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Merck
CN

O9390

N-草酰基甘氨酸

≥98% (HPLC), α-ketoglutarate-dependent enzyme inhibitor, solid

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关于此项目

经验公式（希尔记法）:
C4H5NO5
化学文摘社编号:
5262-39-5
分子量:
147.09
UNSPSC Code:
12352209
PubChem Substance ID:
329818940
NACRES:
NA.77
MDL number:
MFCD00913253

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产品名称

N-草酰基甘氨酸, ≥98% (HPLC)

SMILES string

OC(=O)CNC(=O)C(O)=O

InChI key

BIMZLRFONYSTPT-UHFFFAOYSA-N

InChI

1S/C4H5NO5/c6-2(7)1-5-3(8)4(9)10/h1H2,(H,5,8)(H,6,7)(H,9,10)

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

solubility

deionized water: >10 mg/mL

storage temp.

2-8°C

Quality Level

100

相关类别

Biochem/physiol Actions

N-草酰甘氨酸是 α-酮戊二酸依赖性酶的抑制剂。
N-草酰甘氨酸是 α-酮戊二酸依赖性酶的抑制剂，并且模仿初始步骤，但不引发羟基化过程。N-草酰甘氨酸已被用于抑制含有 Jumonji C 结构域的组蛋白赖氨酸去甲基化酶。

Features and Benefits

该化合物收录于受体分类和信号转导手册的《谷氨酸/GABA合成与代谢》页面。想要浏览手册的其他页面， 请单击此处。
这种化合物是基因调控和神经科学研究的特色产品。了解更多特色基因调控和神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000413952
0000413950
0000413952
0000413950
0000339566

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Shan Shao et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(8), 10860-10870 (2020-06-28)
The tumor microenvironment (TME) is a crucial factor in cancer progression. In breast cancer, cancer-associated fibroblasts (CAFs) and the derived stromal components have been recognized as comprising the majority of the pathological structure of the TME. In this study, we
Gulzhan Raiymbek et al.
eLife, 9 (2020-03-21)
H3K9 methylation (H3K9me) specifies the establishment and maintenance of transcriptionally silent epigenetic states or heterochromatin. The enzymatic erasure of histone modifications is widely assumed to be the primary mechanism that reverses epigenetic silencing. Here, we reveal an inversion of this
Lisa P Elia et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(17), 3332-3344 (2019-01-31)
Deficient progranulin levels cause dose-dependent neurological syndromes: haploinsufficiency leads to frontotemporal lobar degeneration (FTLD) and nullizygosity produces adult-onset neuronal ceroid lipofuscinosis. Mechanisms controlling progranulin levels are largely unknown. To better understand progranulin regulation, we performed a genome-wide RNAi screen using
Nathaniel W Mabe et al.
Cell reports, 33(5), 108341-108341 (2020-11-05)
Dysregulated gene expression is a common feature of cancer and may underlie some aspects of tumor progression, including tumor relapse. Here, we show that recurrent mammary tumors exhibit global changes in gene expression and histone modifications and acquire dependence on
Xiongwen Cao et al.
Cell reports, 30(12), 4152-4164 (2020-03-27)
Histone methyl groups can be removed by demethylases. Although LSD1 and JmjC domain-containing proteins have been identified as histone demethylases, enzymes for many histone methylation states or sites are still unknown. Here, we perform a screening of a cDNA library
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谷氨酸/GABA合成和代谢

谷氨酰胺是谷氨酸和GABA生物合成的常用前体。谷氨酰胺可以利用不同的谷氨酰胺载体在神经元和星形胶质细胞进行细胞内外转运。神经递质谷氨酸可以通过磷酸盐活化的谷氨酰胺酶的作用从谷氨酰胺合成。

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