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O9512

奥沙利铂

Name: 奥沙利铂
Brand: SIGMA

Apoptosis inducer, powder

别名:

[SP-4-2-(1R-反式)]-(1,2-环己二胺-N,N′)[乙二酸(2-)-O,O’]铂

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关于此项目

经验公式（希尔记法）:

C₈H₁₄N₂O₄Pt

化学文摘社编号:

61825-94-3

分子量:

397.29

UNSPSC Code:

12352200

PubChem Substance ID:

329818942

NACRES:

NA.77

MDL number:

MFCD00866327

Form:

powder

Quality level:

100

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产品名称

奥沙利铂, powder

form

powder

Quality Level

100

originator

Sanofi Aventis

storage temp.

2-8°C

SMILES string

O=C1O[Pt]OC1=O.N[C@@H]2CCCC[C@H]2N

InChI

1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1

InChI key

ZROHGHOFXNOHSO-BNTLRKBRSA-L

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Application

奥沙利铂已被用于：

通过细胞活力测定，作为结肠直肠腺癌 SW480 细胞中的化学治疗剂
用于通过 MTT 比色法监测肝细胞癌 HepG2 和 HepG2/R 细胞中的细胞存活率
确定对人乳腺癌 MDA-MB-231 细胞的生长抑制作用

Biochem/physiol Actions

奥沙利铂是一种铂类似物，通过结合 DNA 并形成链间和链内交联，阻止复制和转录，进而导致 DNA 损伤和细胞死亡。奥沙利铂是一种具有抗结直肠癌活性的抗肿瘤药物；细胞毒性随着与 DNA 的加合物的形成而产生。奥沙利铂是用于治疗结直肠癌的已批准药物。它是 FOLFOX（亚叶酸：5-FU：奥沙利铂，其比例分别为 1：10：1 的微摩尔浓度）中的活性成分。奥沙利铂在患者中引起急性和慢性神经毒性（以剂量依赖性方式），并且通过减少或停止药物是可逆的。

Features and Benefits

该化合物是 ADME Tox 和细胞凋亡研究的特色产品。发现更多 ADME Tox 和凋亡的特色产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。

该化合物是由 Sanofi Aventis开发。如需浏览其他药物开发的化合物和批准的药物/候选药物清单，请单击此处。

pictograms

GHS08,GHS05

signalword

Danger

hcodes

H317,H318,H334,H341,H351,H360FD,H362,H372

pcodes

P260 - P263 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Carc. 2 - Eye Dam. 1 - Lact. - Muta. 2 - Repr. 1B - Resp. Sens. 1B - Skin Sens. 1 - STOT RE 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Expression of an oncogenic BARD1 splice variant impairs homologous recombination and predicts response to PARP-1 inhibitor therapy in colon cancer

Ozden O, et al.

Scientific Reports, 6, 26273-26273 (2016)

Appendiceal Cancer Patient-Specific Tumor Organoid Model for Predicting Chemotherapy Efficacy Prior to Initiation of Treatment: A Feasibility Study

Votanopoulos KI, et al.

Annals of Surgical Oncology, 1-9 (2018)

SUMOylation alterations are associated with multidrug resistance in hepatocellular carcinoma

Qin Y, et al.

Molecular Medicine Reports, 9(3), 877-881 (2014)

Modern multidisciplinary treatment of rectal cancer based on staging with magnetic resonance imaging leads to excellent local control, but distant control remains a challenge.

S M E Engelen et al.

European journal of cancer (Oxford, England : 1990), 49(10), 2311-2320 (2013-04-11)

The purpose of this multicenter cohort study was to evaluate whether a differentiated treatment of primary rectal cancer based on magnetic resonance imaging (MRI) can reduce the number of incomplete resections and local recurrences and improve recurrence-free and overall survival.

Oxaliplatin-induced loss of phosphorylated heavy neurofilament subunit neuronal immunoreactivity in rat DRG tissue

Jamieson SMF, et al.

Molecular Pain, 5(1), 66-66 (2009)

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全球贸易项目编号

货号	GTIN
O9512-5MG	04061834248903

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