跳转至内容
Merck
CN

P0027

恩波吡维铵 双羟萘酸盐 水合物

≥98% (HPLC), androgen receptor inhibitor, powder

别名:

PP, 6-(二甲基氨基)-2-[2-(2,5-二甲基-1-苯基-1H-吡咯-3-基)乙烯基]-1-甲基-4,4′-亚甲基双[3-羟基-2-萘羧酸](2:1)-喹啉, NSC 223622, 恩波吡维铵

登录 查看组织和合同定价。

选择尺寸

关于此项目

经验公式（希尔记法）:
C26H28N3 · 0.5 C23H14O6 · xH2O
化学文摘社编号:
3546-41-6
分子量:
575.70 (anhydrous basis)
UNSPSC Code:
51111800
PubChem Substance ID:
329819982
NACRES:
NA.77

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

恩波吡维铵 双羟萘酸盐 水合物, ≥98% (HPLC)

SMILES string

O.CN(C)c1ccc2[n+](C)c(\C=C\c3cc(C)n(c3C)-c4ccccc4)ccc2c1.CN(C)c5ccc6[n+](C)c(\C=C\c7cc(C)n(c7C)-c8ccccc8)ccc6c5.Oc9c(cc%10ccccc%10c9Cc%11c(O)c(cc%12ccccc%11%12)C([O-])=O)C([O-])=O

InChI

1S/2C26H28N3.C23H16O6.H2O/c2*1-19-17-21(20(2)29(19)24-9-7-6-8-10-24)11-13-23-14-12-22-18-25(27(3)4)15-16-26(22)28(23)5;24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;/h2*6-18H,1-5H3;1-10,24-25H,11H2,(H,26,27)(H,28,29);1H2/q2*+1;;/p-2

InChI key

FGNOZQNUEDSSTR-UHFFFAOYSA-L

assay

≥98% (HPLC)

form

powder

color

red

solubility

DMSO: >10 mg/mL

storage temp.

room temp

Quality Level

100

相关类别

Application

吡维胺盐水合物在急变期慢性髓性白血病 (BP-CML) 和人胚胎肾细胞 (HEK293) 中可作为酪蛋白激酶α (CK1α) 的激动剂。它还可用作维尔姆斯瘤中的β-连环蛋白的抑制剂。

Biochem/physiol Actions

恩波吡维铵是一种有效的雄激素受体抑制剂。
恩波吡维铵是一种有效的雄激素受体抑制剂。雄激素受体（AR）是一种核激素受体/转录因子，存在于细胞质中，可被睾丸激素和二氢睾丸激素激活。AR抑制剂对前列腺癌具有潜在的治疗作用；已经发现了其竞争性抑制剂和化学去势方法，但是两种疗法都具有不良的副作用和/或抗药性。通过筛选非竞争性抑制剂，发现了恩波吡维铵 可以作为AR抑制剂。与竞争性抑制剂相比，该化合物不会与AR的配体结合域结合或阻止AR占据DNA，但它能够通过独特的信号传导机制来抑制AR依赖性基因表达。它比传统的竞争性AR拮抗剂更有效，并且与其他AR抑制剂具有协同作用。

Features and Benefits

该化合物是受体分类及信号转导手册上核受体（类固醇）页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000503163
0000503164
0000503163
0000503164
0000289604

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Mehmet Mert et al.
Environmental science and pollution research international, 26(21), 21495-21510 (2019-05-28)
This study estimated unbalanced panel data analysis to investigate the relationship among CO2 emissions, GDP, renewable and non-renewable energy utilization, and foreign direct investment (FDI) inflow in 26 European countries. Moreover, we investigated the role of environmental regulations in validation
C Cabello-Alvarado et al.
Polymers, 11(7) (2019-07-25)
The study of polymeric nanocomposites is a possible alternative to conventional flame retardants. The aim of the present work is to investigate the effects of carbon-nanotubes (CNT) and TiO2 nanoparticles (NPs) on the thermo-mechanical, flammability, and electrical properties of polypropylene
Zahra Anari et al.
Journal of food science, 84(8), 2199-2208 (2019-07-18)
Bioactive anthocyanins from aqueous extracts of muscadine grape pomace were concentrated using osmotic distillation (OD) and direct contact membrane distillation (DCMD) using polypropylene (PP) and poly(ethylene chlorotrifluoroethylene) (ECTFE) membranes. The driving force for OD is created by using a high
Lee-Ping Wang et al.
Journal of chemical theory and computation, 15(8), 4454-4467 (2019-07-19)
Born-Oppenheimer molecular dynamics (BOMD) is a promising simulation method for exploring the possible reaction pathways of a chemical system, but one significant challenge is the increased difficulty of converging the self-consistent field (SCF) calculation that often accompanies the breaking and
Shu-Chuan Liao et al.
Nanomaterials (Basel, Switzerland), 9(7) (2019-07-03)
: Cold plasma is an emerging technology offering many potential applications for regenerative medicine or tissue engineering. This study focused on the characterization of the carboxylic acid functional groups deposited on polymeric substrates using a plasma polymerization process with an
查看所有相关文献

商品

Nuclear Receptors (Steroids)

We offers many products related to Nuclear Receptors (Steroids) for your research needs.

核受体（类固醇）

我们可提供多种核受体（类固醇）相关产品，满足您的各类研究需求。

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持