P0039
PHPS1 钠盐 水合物
≥98% (HPLC)
别名:
4-[2-[1,5-二氢-3-（4-硝基苯基）-5-氧代-1-苯基-4H-吡唑-4-亚基] 肼基]-苯磺酸 钠盐 水合物
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选择尺寸
关于此项目
经验公式（希尔记法）:
C21H15N5O6S · xNa+ · yH2O
化学文摘社编号:
分子量:
465.44 (anhydrous free acid basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
PHPS1 钠盐 水合物, ≥98% (HPLC)
SMILES string
O=C1/C(C(C2=CC=C([N+]([O-])=O)C=C2)=NN1C3=CC=CC=C3)=N/NC4=CC=C(S(=O)([O-])=O)C=C4.[Na+].O
InChI
1S/C21H15N5O6S.Na.H2O/c27-21-20(23-22-15-8-12-18(13-9-15)33(30,31)32)19(14-6-10-17(11-7-14)26(28)29)24-25(21)16-4-2-1-3-5-16;;/h1-13,22H,(H,30,31,32);;1H2/q;+1;/p-1/b23-20+;;
InChI key
KLXUVMQUEDKCKG-JBKNFAMTSA-M
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
red
solubility
DMSO: 10 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
相关类别
Application
苯基亚肼基吡唑啉酮磺酸盐1（PHPS1）钠盐水合物已被用作蛋白酪氨酸磷酸酶（shp2）抑制剂，用于研究其对双酚A（BPA）和壬基苯酚（NP）诱导的MCF7细胞增殖的影响。它还被用作shp2抑制剂，用于研究其体内和体外致动脉粥样硬化或动脉粥样硬化保护作用。
Biochem/physiol Actions
Shp-2 是一种含有 Src 同源-2 (SH2) 的磷酸酶，可调节生长因子信号传导。
Shp-2 是一种含有 Src 同源-2 (SH2) 的磷酸酶，可调节生长因子信号传导。这种酶在哺乳动物组织中广泛表达并在发育中起重要作用。也涉及各种病理状态。PHPS1 是 Shp-2 的选择性抑制剂，阻断 Shp-2 依赖的下游信号通路。
苯基亚肼基吡唑啉酮磺酸盐1（PHPS1）会抑制E2诱导的基因转录和快速的DNA合成。它还会阻断丝裂原激活的蛋白激酶（ERK1/2）活化，并减少香烟烟雾引起的小鼠肺部炎症反应。
Features and Benefits
《受体分类和信号转导》手册的 磷蛋白磷酸酶（酪氨酸） 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Chunmei Fan et al.
Cell reports, 39(4), 110762-110762 (2022-04-28)
Tendon maturation lays the foundation for postnatal tendon development, its proper mechanical function, and regeneration, but the critical cell populations and the entangled mechanisms remain poorly understood. Here, by integrating the structural, mechanical, and molecular properties, we show that post-natal
Increased Cell Proliferation by Various Doses of Xenoestrogen in MFC-7 Cell Through Tyrosine Phosphatase Shp2
Liu W, et al.
American Journal of Bioscience and Bioengineering, 3(6), 178-182 (2015)
SHP2 inhibitor PHPS1 protects against atherosclerosis by inhibiting smooth muscle cell proliferation
Chen J, et al.
BMC Cardiovascular Disorders, 18(1), 72-72 (2018)
Heng Zhou et al.
Journal of molecular medicine (Berlin, Germany), 98(5), 691-705 (2020-04-14)
Cardiac hypertrophy is a complex pathological process, and the molecular mechanisms underlying hypertrophic remodeling have not been clearly elucidated. Leukocyte immunoglobulin-like receptor B4 (lilrb4) is an inhibitory transmembrane protein that is necessary for the regulation of various cellular signaling pathways.
Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptor.
Li J, Kang Y, Wei L, et al.
PLoS ONE, 9(7), e102847-e102847 (2014)
商品
Protein tyrosine phosphatases' catalytic mechanism involves transient phosphorylation.
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