P0040
PP1
≥98% (HPLC), PTK inhibitor, powder
别名:
4-Amino-5-(methylphenyl)-7-(t-butyl)pyrazolo-(3,4-d)pyrimidine
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选择尺寸
关于此项目
经验公式（希尔记法）:
C16H19N5
化学文摘社编号:
分子量:
281.36
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
PP1, ≥98% (HPLC)
SMILES string
Cc1ccc(cc1)-c2nn(c3ncnc(N)c23)C(C)(C)C
InChI key
ZVPDNRVYHLRXLX-UHFFFAOYSA-N
InChI
1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: >20 mg/mL
storage temp.
room temp
Quality Level
Application
PP1已用作：
- 肉瘤(Src)家族激酶(SFK)的抑制剂，如造血细胞激酶(hck)和fyn
- 在海马神经元培养中选择Src酪氨酸激酶抑制剂以测试其对神经突生长的影响
- Src激酶阻滞剂，以测试对溴莫尼定(BMD)诱导的细胞外信号激活激酶(ERK1/2)磷酸化的影响
Biochem/physiol Actions
PP1 是一种有效的选择性 Src 家族蛋白酪氨酸激酶抑制剂。
PP1是一种吡唑嘧啶化合物，作为三磷酸腺苷(ATP)结合的竞争性抑制剂。它还能抑制蛋白酪氨酸激酶(PTK6)，可用于PTK6阳性乳腺癌恶性肿瘤的治疗管理。
Features and Benefits
这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于其他研究领域中关于生物活性小分子的消息。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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