P0042
PP2
≥98% (HPLC), Src-family tyrosine kinase inhibitor, powder
别名:
4-氨基-3-（4-氯苯基）-1-（叔丁基）-1H-吡唑并 [3,4-d] 嘧啶, 4-氨基-5-（4-氯苯基）-7-（叔丁基）吡唑并 [3,4-d] 嘧啶, AG 1879
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选择尺寸
关于此项目
经验公式（希尔记法）:
C15H16ClN5
化学文摘社编号:
分子量:
301.77
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
PP2, ≥98% (HPLC)
SMILES string
CC(C)(C)n1nc(-c2ccc(Cl)cc2)c3c(N)ncnc13
InChI
1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
InChI key
PBBRWFOVCUAONR-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
Quality Level
Application
PP2 已被用于:
- 分析 Src/粘着斑激酶（FAK）信号传导对 IQ 结构域 GTP酶激活蛋白 1 （IQGAP1）介导的失巢凋亡抗性的影响
- 用于 Src 抑制以研究其对非小细胞肺癌 （NSCLC） 细胞中表皮生长因子受体（EGFR） 和核因子E 2 相关因子 2（Nrf2） 磷酸化的影响
- 用于MDA-MB-231 乳腺癌细胞中 SRC的药物抑制
Biochem/physiol Actions
PP2 是非受体酪氨酸激酶（nRTK） 的Src-家族酪氨酸激酶的选择性抑制剂。它对ζ链TCR相关蛋白激酶70（ZAP-70）和 Janus激酶 2（JAK2）的选择性>10000 倍。PP2 在体外和体内有效地减少宫颈癌增殖。
Features and Benefits
该化合物是激酶磷酸酶生物学研究的特色产品。 点击此处 ，发现更多特色激酶磷酸酶生物学产品。在 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
flash_point_f
Not applicable
flash_point_c
Not applicable
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