P0046
绿脓菌素
from Pseudomonas aeruginosa, ≥98% (HPLC), solid, redox-active phenazine
别名:
5-甲基-1-（5H）-吩嗪, Sanasin, Sanazin, 绿脓菌素
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经验公式（希尔记法）:
C13H10N2O
化学文摘社编号:
分子量:
210.23
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
绿脓菌素, from Pseudomonas aeruginosa, ≥98% (HPLC)
SMILES string
CN1c2ccccc2N=C3C(=O)C=CC=C13
InChI
1S/C13H10N2O/c1-15-10-6-3-2-5-9(10)14-13-11(15)7-4-8-12(13)16/h2-8H,1H3
InChI key
YNCMLFHHXWETLD-UHFFFAOYSA-N
biological source
Pseudomonas aeruginosa
assay
≥98% (HPLC)
form
solid
solubility
DMSO: soluble
acetone: soluble
chloroform: soluble
ethanol: soluble
shipped in
wet ice
storage temp.
−20°C
Quality Level
相关类别
Application
绿脓素已作为生物标志物，用以检测 铜绿假单胞菌。
Biochem/physiol Actions
绿脓菌素是一种属于吩嗪颜料的蓝绿色颜料，是氧化还原活性吩嗪。绿脓菌素是一种电子受体，可刺激细菌、肝细胞和人类上皮细胞系中的氧化还原循环。
绿脓菌素是一种属于吩嗪颜料的蓝绿色颜料，是氧化还原活性吩嗪。绿脓菌素是一种电子受体，可刺激细菌、肝细胞和人类上皮细胞系中的氧化还原循环。绿脓菌素增强氧化代谢，又通过减少NADPH来增加细胞内活性氧(ROS)的形成。绿脓菌素还在体外和体内增加气道上皮细胞释放IL-8。这涉及包含氧化剂、蛋白酪氨酸激酶和MAP激酶的信号途径。这些细胞的IL-8分泌与炎性细胞因子协同作用。绿脓菌素被证明在体外加速中性粒细胞凋亡，导致急性炎症的消退，这有利于细菌存活。
Preparation Note
为了制备水溶液，将绿脓菌素溶解在最终所需体积的10％乙醇中，然后加入蒸馏水以完成体积。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
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商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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