P0069
PRIMA-1
≥98% (HPLC), solid
别名:
2,2-二羟基甲基-1-氮杂双环[2.2.2]辛-3-酮
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C9H15NO3
化学文摘社编号:
分子量:
185.22
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
PRIMA-1, ≥98% (HPLC), solid
InChI key
RFBVBRVVOPAAFS-UHFFFAOYSA-N
SMILES string
OCC1(CO)N2CC[C@@H](CC2)C1=O
InChI
1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2
assay
≥98% (HPLC)
form
solid
color
white to off-white
solubility
H2O: >10 mg/mL
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
PRIMA-1 是肿瘤细胞中突变型 p53 活性的选择性再激活剂，是具有突变型 p53 的人肿瘤细胞凋亡的诱导剂和生长抑制剂。
PRIMA-1 是肿瘤细胞中突变型 p53 活性的选择性再激活剂，是具有突变型 p53 的人肿瘤细胞凋亡的诱导剂和生长抑制剂。抑癌基因 p53 中的突变发生在 >50% 的肿瘤细胞中。PRIMA-1 在 μM 浓度下选择性恢复突变 p53 蛋白的序列特异性 DNA 结合和反式激活活性。PRIMA-1 通过功能特异性表位的构象调节，充当突变体 p53 凋亡功能的重新激活剂。
General description
P53 依赖性再激活和大量凋亡诱导分子（PRIMA-1）是一种小分子化合物，在癌症治疗中具有作用。PRIMA-1 刺激人类癌细胞的细胞毒性作用。它诱导红细胞衰亡。
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral - Resp. Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
Federica Eduati et al.
Molecular systems biology, 16(2), e8664-e8664 (2020-02-20)
Mechanistic modeling of signaling pathways mediating patient-specific response to therapy can help to unveil resistance mechanisms and improve therapeutic strategies. Yet, creating such models for patients, in particular for solid malignancies, is challenging. A major hurdle to build these models
PRIMA-1 as a cancer therapy restoring mutant p53: A review
Lewis EJ
Bioscience Horizons, 8 (2015)
Masashi Idogawa et al.
Oncotarget, 5(17), 7540-7548 (2014-10-04)
p53 transduction is a potentially effective cancer therapy but does not result in a good therapeutic response in all human cancers due to resistance to apoptosis. To discover factors that overcome resistance to p53-induced apoptosis, we attempted to identify RNAi
Stimulation of suicidal erythrocyte death by PRIMA-1
Faggio C, et al.
Cellular Physiology and Biochemistry, 35(2), 529-540 (2015)
Effects of PRIMA-1 on chronic lymphocytic leukaemia cells with and without hemizygous p53 deletion
Nahi H, et al.
British Journal of Haematology, 127(3), 285-291 (2004)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持