P0078
Anti-PMP22 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-GAS3, Anti-Growth arrest-specific 3, Anti-Peripheral myelin protein 22
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~22 kDa
种属反应性
human
浓度
~1.0 mg/mL
技术
immunohistochemistry: 2.5-5 μg/mL using biotin/ExtrAvidin™-Peroxidase staining of formalin-fixed, paraffin-embedded human spinal cord sections
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... PMP22(5376)
mouse ... Pmp22(18858)
rat ... Pmp22(24660)
一般描述
PMP22 (peripheral myelin protein-22) is a tetraspan integral membrane protein, that contains four putative transmembrane domains. It is expressed in the peripheral nervous system. PMP22 is produced by myelinating Schwann cells. It is an important constituent of peripheral myelin. This gene is mapped to human chromosome 17p11.2.
免疫原
synthetic peptide corresponding to amino acid residues 118-133 of human PMP22, with an added cysteine, conjugated to KLH. The corresponding sequence differs by 3 amino acids in rat and mouse.
生化/生理作用
Anti-PMP22 recognizes human PMP22.
PMP22 (peripheral myelin protein-22) participates in the progression of CNS (central nervous system) myelin. It modulates self-renewal and chemoresistance of gastric cancer cells. Mutation in PMP22 results in Charcot-Marie tooth disease.
PMP22 plays a role in peripheral nerve myelin formation, cell-cell interactions, and cell proliferation. Overexpression of PMP22 is implicated in the neoplastic transformation of normal tissue to pre-malignant lesions and cancer of the pancreas and osteoblasts.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
制备说明
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze at -20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
法律信息
BiotinTag is a trademark of Sigma-Aldrich Co. LLC
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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