P0099

帕潘立酮

Name: 帕潘立酮
Brand: SIGMA

≥98% (HPLC), risperidone metabolite, powder

别名:

3-[2-[4-（6-氟-1,2-苯并异恶唑-3-基）-1-哌啶基] 乙基]-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶并 [1,2-a] 嘧啶-4-酮, 9-羟基利培酮

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经验公式（希尔记法）:

C₂₃H₂₇FN₄O₃

化学文摘社编号:

144598-75-4

分子量:

426.48

UNSPSC Code:

12352200

PubChem Substance ID:

329820012

NACRES:

NA.77

MDL number:

MFCD00871802

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

主要文件

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产品名称

帕潘立酮, ≥98% (HPLC)

SMILES string

CC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCC(O)C5=N1

InChI key

PMXMIIMHBWHSKN-UHFFFAOYSA-N

InChI

1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3

assay

≥98% (HPLC)

form

powder

color

white to brown

solubility

DMSO: 2 mg/mL, clear (warmed)

originator

Johnson & Johnson

storage temp.

room temp

Quality Level

100

Gene Information

human ... DRD2(1813), HTR2A(3356)

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Application

帕潘立酮已被用作非典型抗精神病药（AAPD），用于研究其预防脂多糖（LPS）激发的产前免疫小鼠精神疾病的功效。它还被用作非典型抗精神病药（AAPD），用于诠释以细菌内毒素脂多糖（LPS）处理的雌性产前小鼠中下丘脑-垂体-肾上腺（HPA）轴的调节。

Biochem/physiol Actions

帕利哌酮属于非典型抗精神病药；利培酮的活性代谢产物。

Features and Benefits

《受体分类和信号转导》手册的多巴胺受体页有该化合物的介绍。想要浏览手册的其他页面，请单击此处。

该化合物由强生开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表，请点击此处。

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

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Lot/Batch Number

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Atypical antipsychotic paliperidone prevents behavioral deficits in mice prenatally challenged with bacterial endotoxin lipopolysaccharide.

Umesh Kumar et al.

European journal of pharmacology, 747, 181-189 (2014-09-23)

Studies on animal models provide enough evidences that old age appearance of psychosis on exposures to various insults during critical period of brain development could be prevented by antipsychotic drug treatment. Presently, gestational intervention of the atypical antipsychotic paliperidone (PAL)

Distinct electrophysiological effects of paliperidone and risperidone on the firing activity of rat serotonin and norepinephrine neurons.

Eliyahu Dremencov et al.

Psychopharmacology, 194(1), 63-72 (2007-05-29)

Paliperidone (9-OH-risperidone) is the main metabolite of the atypical antipsychotic risperidone. While both drugs are potent dopamine (D)2 antagonists, they have quantitative differential affinities for serotonin (5-HT) and norepinephrine (NE) receptor binding sites. The present study aimed to determine if

An evaluation of using rat-derived single-dose neuropharmacokinetic parameters to project accurately large animal unbound brain drug concentrations.

Angela C Doran et al.

Drug metabolism and disposition: the biological fate of chemicals, 40(11), 2162-2173 (2012-08-18)

Previous publications suggest that interstitial fluid compound concentrations (C(ISF)) best determine quantitative neurotherapeutic pharmacology relationships, although confirming large animal C(ISF) remains elusive. Therefore, this work primarily evaluated using respective acute dose, rat-derived unbound brain compound concentration-to-unbound plasma compound concentration ratios

Risk of hyperprolactinemia and sexual side effects in males 10-20 years old diagnosed with autism spectrum disorders or disruptive behavior disorder and treated with risperidone.

Yvette Roke et al.

Journal of child and adolescent psychopharmacology, 22(6), 432-439 (2012-12-14)

The aim of this study was to investigate the long-term treatment effects of risperidone on prolactin levels and prolactin-related side effects in pubertal boys with autism spectrum disorders (ASD) and disruptive behavior disorders (DBD). Physical healthy 10-20-year-old males with ASD

Bacterial degradation of risperidone and paliperidone in decomposing blood.

Danielle M Butzbach et al.

Journal of forensic sciences, 58(1), 90-100 (2012-09-22)

The stability of two benzisoxazole antipsychotics was determined in vitro in decomposing porcine blood inoculated with bacteria, utilizing a high-performance liquid chromatography with ultraviolet and fluorescence detection method for drug quantitation. Stability experiments for risperidone and paliperidone were conducted at

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帕潘立酮

≥98% (HPLC), risperidone metabolite, powder

选择尺寸

关于此项目

主要文件

属性

产品名称

SMILES string

InChI key

InChI

assay

form

color

solubility

originator

storage temp.

Quality Level

Gene Information

相关类别

说明

Application

Biochem/physiol Actions

Features and Benefits

安全信息

pictograms

signalword

hcodes

pcodes

Hazard Classifications

存储类别

wgk

flash_point_f

flash_point_c

ppe

文件

分析证书(COA)

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