Merck
CN

P0099

Sigma-Aldrich

帕潘立酮

≥98% (HPLC)

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别名:
3-[2-[4-(6-氟-1,2-苯并异恶唑-3-基)-1-哌啶基] 乙基]-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶并 [1,2-a] 嘧啶-4-酮, 9-羟基利培酮
Empirical Formula (Hill Notation):
C23H27FN4O3
分子量:
426.48
MDL编号:
PubChem化学物质编号:

质量水平

检测方案

≥98% (HPLC)

形式

powder

颜色

white to brown

溶解性

DMSO: 2 mg/mL, clear (warmed)

创始人

Johnson & Johnson

储存温度

room temp

SMILES string

CC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCC(O)C5=N1

InChI

1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3

InChI key

PMXMIIMHBWHSKN-UHFFFAOYSA-N

Gene Information

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此商品
1491809PZ0247PZ0380
Paliperidone ≥98% (HPLC)

Sigma-Aldrich

P0099

帕潘立酮

Paliperidone United States Pharmacopeia (USP) Reference Standard

USP

1491809

帕潘立酮

PF-04979064 ≥98% (HPLC)

Sigma-Aldrich

PZ0247

PF-04979064

PF-04447943 ≥98% (HPLC)

Sigma-Aldrich

PZ0380

PF-04447943

form

powder

form

-

form

powder

form

powder

color

white to brown

color

-

color

white to beige

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

-

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

originator

Johnson & Johnson

originator

-

originator

-

originator

-

storage temp.

room temp

storage temp.

2-8°C

storage temp.

room temp

storage temp.

room temp

应用

帕潘立酮已被用作非典型抗精神病药(AAPD),用于研究其预防脂多糖(LPS)激发的产前免疫小鼠精神疾病的功效。它还被用作非典型抗精神病药(AAPD),用于诠释以细菌内毒素脂多糖(LPS)处理的雌性产前小鼠中下丘脑-垂体-肾上腺(HPA)轴的调节。

生化/生理作用

帕利哌酮属于非典型抗精神病药;利培酮的活性代谢产物。

特点和优势

《受体分类和信号转导》手册的多巴胺受体页有该化合物的介绍。想要浏览手册的其他页面, 请单击此处
该化合物由 强生开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表,请点击此处

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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Psychopharmacology, 194(1), 63-72 (2007-05-29)
Paliperidone (9-OH-risperidone) is the main metabolite of the atypical antipsychotic risperidone. While both drugs are potent dopamine (D)2 antagonists, they have quantitative differential affinities for serotonin (5-HT) and norepinephrine (NE) receptor binding sites. The present study aimed to determine if
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