P0184
Pseudomonas exotoxin A
from Pseudomonas aeruginosa, protein synthesis inhibitor, lyophilized powder
产品名称
假单胞菌外毒素 A 来源于绿脓假单胞菌, lyophilized powder
表单
lyophilized powder
质量水平
组成
Protein, ~30% E1%/280
储存温度
2-8°C
一般描述
Pseudomonas exotoxin A is secreted by Pseudomonas aeruginosa. It is a member of the family mono-ADP-ribosyltransferases.
生化/生理作用
Pseudomonas exotoxin A functions as an anticancer agent.
It catalyses the transfer of ADP-ribose moiety of NAD+ to the histidine imidazole ring of diphthamide.
Shown to be toxic to animals and to cell lines, and to inhibit protein synthesis via ADP ribosylation of elongation factor 2.
It catalyses the transfer of ADP-ribose moiety of NAD+ to the histidine imidazole ring of diphthamide.
Shown to be toxic to animals and to cell lines, and to inhibit protein synthesis via ADP ribosylation of elongation factor 2.
包装
Package size based on protein content.
外形
Lyophilized powder containing Tris buffer, EDTA, NaCl and lactose
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
高风险级别生物产品--毒素类产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
B H Iglewski et al.
Infection and immunity, 15(1), 138-144 (1977-01-01)
Previous studies showed that Pseudomonas aeruginosa exotoxin A (PA toxin) catalyzes nicotinamide adenine dinucleotide (NAD)-dependent inhibition of protein synthesis in a rabbit reticulocyte lysate and transfer of radioactivity from [14C]adenine-labeled NAD to a protein having the same molecular weight as
Preparation of Pseudomonas exotoxin A.
K J Kozak et al.
Methods in enzymology, 165, 147-152 (1988-01-01)
Pseudomonas exotoxin A: from virulence factor to anti-cancer agent
Wolf P and Elsasser-Beile U
International Journal of Medical Microbiology : IJMM, 299(3), 161-176 (2009)
Mutations in the Elongation Factor 2 Gene Which Confer Resistance to Diphtheria Toxin and Pseudomonas Exotoxin A GENETIC AND BIOCHEMICAL ANALYSES
Foley BT, et al.
The Journal of Biological Chemistry, 270(39), 23218-23225 (1995)
J L Middlebrook et al.
Canadian journal of microbiology, 23(2), 183-189 (1977-02-01)
The sensitivities of 21 mammalian cell lines to the exotoxins of Pseudomonas aeruginosa and Corynebacterium diphtheriae were measured. Each line exhibited 1-4 log differences in sensitivities to the two toxins. No species-specific sensitivities were noted for Pseudomonas exotoxin while diphtheria
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