P0244
Anti-PKR (ET-20) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
别名:
Anti-Interferon-induced, double-stranded RNA-activated protein kinase (ET-20)
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 68 kDa
species reactivity
human
technique(s)
microarray: suitable, western blot: 1:2,000 using a whole cell extract of the human epitheloid carcinoma HeLa cell line induced with interferon-γ
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... EIF2AK2(5610)
General description
PKR is a double-stranded RNA-dependent serine/threonine kinase that regulates antiproliferative and antiviral functions of interferons. PKR also functions as a translational inhibitor. In genotoxic environments, PKR mediates CDC2 ubiquitination and G2 arrest in cells . Anti-PKR is antibody is specific for human PKR (68 kDa).
Immunogen
C-terminus of human PKR (amino acids 531-550), conjugated to KLH
Application
Anti-PKR (ET-20) antibody I suitable for use in western blot (1:2,000 using a whole cell extract of the human epitheloid carcinoma HeLa cell line induced with interferon-γ) and microarray.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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法规信息
低风险生物材料
常规特殊物品
此项目有
New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses.
Yoon, C., H., et al.
EMBO Reports, 393-9, 2010-2010 (2010)
K Kawakubo et al.
Virology, 264(1), 106-114 (1999-11-02)
The double-stranded RNA-dependent protein kinase PKR is an interferon-inducible enzyme that possesses antiviral and antiproliferative activities. We examined expression of PKR transcripts in human placenta tissue and cultured human amnion U cells. Alternative exon 2 structures were identified and characterized
H D Robertson et al.
Biochimie, 78(11-12), 909-914 (1996-01-01)
A model is presented for the regulation of the double-stranded RNA (dsRNA)-activated mammalian protein kinase PKR, which is involved in protein synthesis inhibition and the antiviral response in cells. A series of previous findings abut PKROs behavior are reviewed, including
Z Xu et al.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 18(8), 609-616 (1998-09-03)
The double-stranded RNA-dependent protein kinase (PKR) is a serine/threonine kinase that plays an important role in the antiviral activities of interferon (IFN). To determine the organization and regulation of the PKR locus, lambda phage and bacterial artificial chromosome (BAC) clones
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