P0389
青霉素 来源于蜡样芽胞杆菌
lyophilized powder, ≥1500.00 units/mg protein (using benzylpenicillin)
别名:
β-内酰胺酶 I 来源于蜡样芽胞杆菌, β-内酰胺酶 II, 头孢菌素, 青霉素酰氨基-β-内酰胺水解酶
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
Specific activity:
≥1500.00 units/mg protein (using benzylpenicillin)
Biological source:
Bacillus sp. (Bacillus cereus)
产品名称
青霉素 来源于蜡样芽胞杆菌, lyophilized powder, ≥1500.00 units/mg protein (using benzylpenicillin)
biological source
Bacillus sp. (Bacillus cereus)
form
lyophilized powder
specific activity
≥1500.00 units/mg protein (using benzylpenicillin)
composition
Protein, ~10%
technique(s)
activity assay: suitable
application(s)
diagnostic assay manufacturing
shipped in
wet ice
storage temp.
2-8°C
Quality Level
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Analysis Note
通过缩二脲法测定的蛋白质。
Application
用于生产青霉素。
用于生产青霉素。来自蜡状芽孢杆菌的青霉素酶与来自枯草芽孢杆菌的青霉素酶进行了比较研究，其中米氏常数，Ph/活性曲线的形状和免疫学性质显示出显着不同。
青霉素酶可用于降低严重青霉素反应患者的青霉素水平。
Biochem/physiol Actions
青霉素酶特异性催化青霉素的 β-内酰胺环的水解。
General description
来自蜡状芽孢杆菌的青霉素酶在纯化时显示含有三种不同的物质，并通过沉降分析、氨基末端分析和垂直丙烯酰胺凝胶电泳检查均一性。
Other Notes
一个单元将在 pH7.0，25℃ 下，每分钟水解 1.0 μmole 指定的底物。以苄青霉素单位出售。该国际单位（使用苄青霉素作为底物）约等于 600 Levy 或 75 Pollock 单位。
Physical form
含有磷酸盐和柠檬酸盐缓冲盐的冻干粉末
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
常规特殊物品
此项目有
Cristian Piras et al.
Chemical science, 13(6), 1746-1758 (2022-03-15)
Large-scale population screening for early and accurate detection of disease is a key objective for future diagnostics. Ideally, diagnostic tests that achieve this goal are also cost-effective, fast and easily adaptable to new diseases with the potential of multiplexing. Mass
Junichiro Marui et al.
Journal of bioscience and bioengineering, 110(1), 8-11 (2010-06-15)
Aspergillus oryzae penicillin biosynthetic genes were clustered. The penicillin production was positively regulated by VeA, a global gene regulator required for transcriptional expression of the penicillin biosynthetic genes. Overexpression of the biosynthetic genes by a strong promoter yielded a greater
Anaphylactic shock after therapy with penicillinase.
A L HYMAN
Journal of the American Medical Association, 169(6), 593-594 (1959-02-07)
Properties of penicillinase from Bacillus cereus 569.
J Imsande et al.
The Journal of biological chemistry, 245(9), 2205-2212 (1970-05-10)
M A van Opstal et al.
Journal of pharmaceutical and biomedical analysis, 8(1), 49-60 (1990-01-01)
An automated assay for the determination of penicillin in formulations suitable for use in pharmaceutical quality control is presented. The method is based on the classical iodometric penicillin assay which is incorporated in a flow injection analysis (FIA) system. The
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