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Merck
CN

P0424

前列腺素F2Α氨丁三醇盐α 三羟甲基氨基甲烷盐

≥99%, synthetic, powder

别名:

(5Z,9α,11α,13E,15S）-9,11,15-三羟基前列腺-5,13-二烯酸 三羟甲基氨基甲烷盐, 前列腺素 f 2α−Tris

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关于此项目

经验公式（希尔记法）:
C20H34O5 · C4H11NO3
化学文摘社编号:
38562-01-5
分子量:
475.62
NACRES:
NA.77
PubChem Substance ID:
24898103
eCl@ss:
42020658
UNSPSC Code:
12352401
EC Number:
254-002-3
MDL number:
MFCD00077863
Beilstein/REAXYS Number:
4087514

主要文件

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产品名称

前列腺素F2Α氨丁三醇盐α 三羟甲基氨基甲烷盐, ≥99%, synthetic, powder

InChI key

IYGXEHDCSOYNKY-RZHHZEQLSA-N

InChI

1S/C20H34O5.C4H11NO3/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25;5-4(1-6,2-7)3-8/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25);6-8H,1-3,5H2/b7-4-,13-12+;/t15-,16+,17+,18-,19+;/m0./s1

SMILES string

NC(CO)(CO)CO.[H][C@]1(C\C=C/CCCC(O)=O)[C@@H](O)C[C@@H](O)[C@]1([H])\C=C\[C@@H](O)CCCCC

biological source

synthetic

assay

≥99%

form

powder

color

white

solubility

H2O: 1 mg/mL
ethanol: 50 mg/mL

functional group

carboxylic acid
hydroxyl

shipped in

ambient

storage temp.

−20°C

Quality Level

200

Gene Information

human ... PTGFR(5737)

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相关类别

Biochem/physiol Actions

诱导分娩的溶黄体前列腺素。肺、冠状和脑小动脉床的强效血管收缩剂。
诱导分娩的溶黄体前列腺素。肺、冠状和脑小动脉床的强效血管收缩剂。也可刺激平滑肌（如支气管）收缩，可能与哮喘有关。这种作用至少部分通过速激肽释放介导。
诱导分娩的溶黄体前列腺素。肺、冠状和脑小动脉床的强效血管收缩剂。子宫内膜 PG F 2α 之间的正反馈环黄体溶解由黄体催产素完成 。

General description

水溶液在2-8°C下可稳定保存30天，进行一次性使用分装后，可在−0°C下稳定保存数月。 应避免反复冻/融循环。

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000485546
0000485546
0000499738
0000499738
0000490457

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J W Barnard et al.
Journal of applied physiology (Bethesda, Md. : 1985), 72(6), 2469-2474 (1992-06-01)
To characterize the interactions between prostaglandin F2 alpha and prostacyclin in controlling tone in the pulmonary circulation, isolated rat lungs were ventilated, perfused with blood, and subjected to challenge by prostaglandin F2 alpha in increasing doses. The pulmonary resistance was
J B Salom et al.
European journal of pharmacology, 203(1), 33-39 (1991-10-02)
We examined the effects of extracellular Ca2+ withdrawal and of Ca2+ entry blockers on goat cerebrovascular responses to prostaglandin F2 alpha (PGF2 alpha). We measured isometric tension in isolated middle cerebral arteries, and cerebral blood flow (CBF) in unanesthetized animals.
W Wuttke et al.
Steroids, 63(5-6), 299-305 (1998-06-10)
During the second half of the luteal phase, the human corpus luteum becomes responsive to regular luteinizing hormone (LH) pulses. These LH pulses stimulate progesterone secretion tonically, and during this tonic stimulation, additional LH-independent progesterone pulses occur, which are particularly
A R Fuchs
Journal of steroid biochemistry, 27(4-6), 1073-1080 (1987-01-01)
The oxytocin-neurophysin gene is expressed in several nontraditional sites within the endocrine system. In the ovary its expression in the corpora lutea is initiated by ovulation. Ovarian oxytocin concentrations reach maximal levels around day 11 of luteal cycle and fall
A Gogny et al.
Theriogenology, 74(9), 1531-1538 (2010-08-17)
The aim of this in vitro study was to compare the uterokinetic activity of oxytocin and dinoprost, the natural PGF2α, with or without aglepristone, in canine myometrial fibers. Thirty-three bitches were allocated into one of four groups, depending on their
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