P0547
喷他脒 羟乙基磺酸盐
NMDA glutamate receptor antagonist, powder
别名:
1,5-双（ p -脒基苯氧基）戊烷双（2-羟乙磺酸盐）, 4,4′-二苯甲脒双
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关于此项目
线性分子式:
CH2[CH2CH2OC6H4C(=NH)NH2]2·2HOCH2CH2SO3H
化学文摘社编号:
分子量:
592.68
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
喷他脒 羟乙基磺酸盐, powder
表单
powder
质量水平
mp
188-194 °C (lit.)
抗生素抗菌谱
fungi
作用机制
enzyme | inhibits
创始人
Celgene
储存温度
−20°C
SMILES字符串
OCCS(O)(=O)=O.OCCS(O)(=O)=O.NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(N)=N)cc1
InChI
1S/C19H24N4O2.2C2H6O4S/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23;2*3-1-2-7(4,5)6/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23);2*3H,1-2H2,(H,4,5,6)
InChI key
YBVNFKZSMZGRAD-UHFFFAOYSA-N
基因信息
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警示用语：
Warning
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
Drug-induced functional cardiotoxicity screening in stem cell-derived human and mouse cardiomyocytes: effects of reference compounds
Himmel HM
Journal of Pharmacological and Toxicological Methods, 68(1), 97-111 (2013)
Anti-leishmanial lindenane sesquiterpenes from Hedyosmum angustifolium
Acebey L, et al.
Planta Medica, 76(04), 365-368 (2010)
I J Reynolds et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 12(3), 970-975 (1992-03-01)
Acquired immunodeficiency syndrome (AIDS) is frequently associated with dementia. The wide spectrum of neurological abnormalities associated with this dementia may involve a neurotoxin that activates the NMDA subtype of glutamate receptor in neurons. We have found that the antimicrobial agent
Deiziane V S Costa et al.
Frontiers in cellular and infection microbiology, 11, 739874-739874 (2021-09-28)
The involvement of the enteric nervous system, which is a source of S100B, in Clostridioides difficile (C. difficile) infection (CDI) is poorly understood although intestinal motility dysfunctions are known to occur following infection. Here, we investigated the role of S100B
Lucia Acebey et al.
Planta medica, 76(4), 365-368 (2009-10-16)
The aim of this work is the isolation of anti-leishmanial compounds from the ethyl acetate extracts of the bark of HEDYOSMUM ANGUSTIFOLIUM. We have successfully isolated and characterized five sesquiterpenes: one new compound (oxyonoseriolide, 1), one compound isolated for the
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