产品名称
5-Propyl-2-thiouracil, ≥98%
InChI key
RWJRFPUNLXBCML-UHFFFAOYSA-N
SMILES string
CCCC1=CNC(=S)NC1=O
InChI
1S/C7H10N2OS/c1-2-3-5-4-8-7(11)9-6(5)10/h4H,2-3H2,1H3,(H2,8,9,10,11)
biological source
synthetic (organic)
assay
≥98%
form
powder
solubility
1 M NH4OH: 50 mg/mL, clear to slightly hazy, colorless to light yellow
Quality Level
Application
5-Propyl-2-thiouracil (PTU) is used to induce and study mechanisms of hypothyroidism at the levels of thyroid hormone biosynthesis and gene regulation.
Nadine Bohni et al.
PloS one, 8(5), e64006-e64006 (2013-05-24)
Natural products (NPs) are an attractive source of chemical diversity for small-molecule drug discovery. Several challenges nevertheless persist with respect to NP discovery, including the time and effort required for bioassay-guided isolation of bioactive NPs, and the limited biomedical relevance
Ayumi Nagasawa-Masuda et al.
PloS one, 12(4), e0174633-e0174633 (2017-04-04)
Vascular regression is essential to remove redundant vessels during the formation of an efficient vascular network that can transport oxygen and nutrient to every corner of the body. However, no mechanism is known to explain how major blood vessels regress
Alexander G Little et al.
BMC biology, 11, 26-26 (2013-03-28)
Thyroid hormone (TH) is best known for its role in development in animals, and for its control of metabolic heat production (thermogenesis) during cold acclimation in mammals. It is unknown whether the regulatory role of TH in thermogenesis is derived
Alessandra Gentili et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 33(12), 1793-1802 (2016-10-04)
This paper describes a rapid method for confirming residues of thyreostats in meat-based baby foods by using liquid chromatography - dual polarity electrospray - tandem mass spectrometry (LC-ES(±)-MS/MS). Six thioureylenes, belonging to the group of thiouracil and imidazole, were selected
Marion F Haug et al.
Frontiers in zoology, 7, 8-8 (2010-03-03)
Visual acuity, the ability of the visual system to distinguish two separate objects at a given angular distance, is influenced by the optical and neuronal properties of the visual system. Although many factors may contribute, the ultimate limit is photoreceptor
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