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Merck
CN

P0778

Sigma-Aldrich

Pindolol

≥98% (TLC), powder

别名:

1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol, 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol

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关于此项目

经验公式（希尔记法）:
C14H20N2O2
CAS Number:
13523-86-9
分子量:
248.32
EC 号:
236-867-9
MDL编号:
MFCD00010530
UNSPSC代码:
12352200
PubChem化学物质编号:
24277795
NACRES:
NA.77

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质量水平

200

方案

≥98% (TLC)

表单

powder

颜色

white to off-white

mp

167-171 °C (lit.)

溶解性

0.1 M NaOH: 0.2 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL
0.1 M HCl: 20 mg/mL
acetic acid: 50 mg/mL
H2O: insoluble

创始人

Novartis

储存温度

2-8°C

SMILES字符串

CC(C)NCC(O)COc1cccc2[nH]ccc12

InChI

1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3

InChI key

JZQKKSLKJUAGIC-UHFFFAOYSA-N

基因信息

human ... ADRB1(153), ADRB2(154), HTR1A(3350)

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应用

Pindolol has been used in intestinal transport and metabolism assays and cassette mix preparation.

生化/生理作用

β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator. Pindolol is a non-cardioselective beta-adrenergic blocking agent. It possesses intrinsic sympathomimetic activity.
β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator.

特点和优势

Shelf-life of the powder is at least five years.
This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000443243
0000443243
0000406844
0000406844
0000365083

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Pindolol: a review of its pharmacology, pharmacokinetics, clinical uses, and adverse effects
Golightly L K
Pharmacotherapy, 2(3), 134-147 (1982)
The biotransformation of prasugrel, a new thienopyridine prodrug, by the human carboxylesterases 1 and 2
Williams E T, et al.
Drug Metabolism and Disposition (2008)
Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts
Pelkonen L, et al.
European Journal of Pharmaceutical Sciences, 162-168 (2017)
Maria J Portella et al.
The Journal of clinical psychiatry, 72(7), 962-969 (2010-11-03)
Since depression entails not only dramatic personal disruption but also a huge amount of medical and socioeconomic burden, slowness of antidepressant action and difficulties to attain remission are entangled issues to be solved. Given the controversial previous findings with enhancing
Francesc Artigas et al.
Current drug targets, 7(2), 139-147 (2006-02-16)
Pindolol, a partial beta-adrenoceptor/5-HT1A receptor antagonist was first used to accelerate the onset of action of antidepressant drugs in 1994. Since then, it has been used in more than a dozen controlled trials to examine whether it can reduce the
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Chromatograms

application for HPLCapplication for HPLC

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