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Merck
CN

P0778

Pindolol

≥98% (TLC), β1-adrenoceptor antagonist, powder

别名:

1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol, 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol

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关于此项目

经验公式（希尔记法）:
C14H20N2O2
化学文摘社编号:
13523-86-9
分子量:
248.32
NACRES:
NA.77
PubChem Substance ID:
24277795
UNSPSC Code:
12352200
EC Number:
236-867-9
MDL number:
MFCD00010530

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产品名称

Pindolol, ≥98% (TLC), powder

InChI key

JZQKKSLKJUAGIC-UHFFFAOYSA-N

InChI

1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3

SMILES string

CC(C)NCC(O)COc1cccc2[nH]ccc12

assay

≥98% (TLC)

form

powder

color

white to off-white

mp

167-171 °C (lit.)

solubility

0.1 M NaOH: 0.2 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL
0.1 M HCl: 20 mg/mL
acetic acid: 50 mg/mL
H2O: insoluble

originator

Novartis

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... ADRB1(153), ADRB2(154), HTR1A(3350)

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相关类别

Application

Pindolol has been used in intestinal transport and metabolism assays and cassette mix preparation.

Biochem/physiol Actions

β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator. Pindolol is a non-cardioselective beta-adrenergic blocking agent. It possesses intrinsic sympathomimetic activity.
β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator.

Features and Benefits

Shelf-life of the powder is at least five years.
This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000494968
0000443243
0000443243
0000406844
0000406844

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Pindolol: a review of its pharmacology, pharmacokinetics, clinical uses, and adverse effects
Golightly L K
Pharmacotherapy, 2(3), 134-147 (1982)
C M Hysek et al.
Emergency medicine journal : EMJ, 27(8), 586-589 (2010-04-10)
MDMA (3,4-methylenedioxymethamphetamine, 'Ecstasy') produces tachycardia and hypertension and is rarely associated with cardiovascular and cerebrovascular complications. In clinical practice, beta-blockers are often withheld in patients with stimulant intoxication because they may increase hypertension and coronary artery vasospasm due to loss
Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts
Pelkonen L, et al.
European Journal of Pharmaceutical Sciences, 162-168 (2017)
The biotransformation of prasugrel, a new thienopyridine prodrug, by the human carboxylesterases 1 and 2
Williams E T, et al.
Drug Metabolism and Disposition (2008)
Maria J Portella et al.
The Journal of clinical psychiatry, 72(7), 962-969 (2010-11-03)
Since depression entails not only dramatic personal disruption but also a huge amount of medical and socioeconomic burden, slowness of antidepressant action and difficulties to attain remission are entangled issues to be solved. Given the controversial previous findings with enhancing
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