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Merck
CN

P1269

Sigma-Aldrich

佛波醇 12,13-二丁酸酯

≥98% (TLC), powder, PKC activator

别名:

二丁酸佛波醇酯

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关于此项目

经验公式（希尔记法）:
C28H40O8
CAS Number:
37558-16-0
分子量:
504.61
Beilstein:
6551234
MDL编号:
MFCD00036783
UNSPSC代码:
12352211
PubChem化学物质编号:
24898178
NACRES:
NA.77

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Product Name

佛波醇 12,13-二丁酸酯, ≥98% (TLC), powder

质量水平

100

方案

≥98% (TLC)

表单

powder

颜色

clear light yellow, film

溶解性

H2O: 30 μM
DMSO: soluble
acetone: soluble
ethanol: soluble

储存温度

−20°C

SMILES字符串

CCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@@H](C=C(CO)C[C@@]3(O)[C@H]2C=C(C)C3=O)[C@@H]4C(C)(C)[C@]14OC(=O)CCC

InChI

1S/C28H40O8/c1-7-9-20(30)35-24-16(4)27(34)18(22-25(5,6)28(22,24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12,16,18-19,22,24,29,33-34H,7-10,13-14H2,1-6H3/t16-,18+,19-,22-,24-,26-,27-,28-/m1/s1

InChI key

BQJRUJTZSGYBEZ-YVQNUNKESA-N

基因信息

mouse ... Prkcd(18753)

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相关类别

应用

佛波醇12,13-二丁酸酯（二丁酸佛波醇酯）已用作蛋白激酶C(PKC)激活剂，用于研究其对人有机阴离子转运蛋白4(hOAT4)活性的影响。作为PKC激活剂，它也已用于分析其对HL-1细胞中半乳凝素-3表达和基质产生的影响。

生化/生理作用

佛波醇12,13-二丁酸酯(PDBu)是蛋白激酶C(PKC)的强效激活剂。它的亲水性高于佛波醇12-肉豆蔻酸酯13-乙酸酯(PMA)，方便在组织培养中将PDBu洗出细胞。PDBu可激活原代人脐静脉内皮细胞的内皮型一氧化氮合酶表达，进而影响PKCα和ε表达。

特点和优势

疏水性低于 PMA，更容易在组织培养中洗掉细胞。

制备说明

贮备液不能在水性介质中制备；在水介质中稀释至工作浓度前，溶于可溶于水的有机溶剂中。

免责声明

光敏

警示用语：

Danger

危险分类

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCZ2630
MKCX6860
MKCX2580
MKCX2528
MKCX1555

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