P1319
促甲状腺素释放激素
≥98% (HPLC), powder
别名:
L-焦谷氨酰-L-组氨酰-L-脯氨酰胺, TRF, TRH, pGlu-His-Pro 酰胺, 促甲状腺素释放素
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关于此项目
经验公式（希尔记法）:
C16H22N6O4
化学文摘社编号:
分子量:
362.38
UNSPSC Code:
51111800
NACRES:
NA.32
PubChem Substance ID:
EC Number:
246-143-4
Beilstein/REAXYS Number:
770238
MDL number:
产品名称
促甲状腺素释放激素, ≥98% (HPLC), powder
InChI key
XNSAINXGIQZQOO-SRVKXCTJSA-N
InChI
1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
SMILES string
NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]3CCC(=O)N3
biological source
human
assay
≥98% (HPLC)
form
powder
mol wt
362.38
storage condition
(Keep container tightly closed in a dry and well-ventilated place)
technique(s)
activity assay: suitable
impurities
22.6-23.8% Nitrogen
51.9-54.1% carbon
solubility
water: 25 mg/mL, cloudy, colorless to faintly yellow
storage temp.
−20°C
Quality Level
Gene Information
human ... TRH(7200), TRHR(7201)
mouse ... Trhr(22045)
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Biochem/physiol Actions
促进垂体前叶生成和分泌促甲状腺素 (TSH)。
Thyrotropin releasing hormone (TRH) stimulates production and secretion of thyrotropin (TSH) and prolactin from the anterior pituitary.
It also plays a vital role as a neurotransmitter and neuromodulator. Thyrotropin-releasing hormone modulates human hair follicle functions and plays a vital role in stimulating hair growth.TRH receptor activated by TRH activates various signal transduction pathways, which mediates the formation of two-second messenger molecules, inositol 1,4,5-trisphosphate, and 1,2-diacylglycerol. TRH expressed in pancreatic β cells aids in the positive regulation of insulin secretion.
It also plays a vital role as a neurotransmitter and neuromodulator. Thyrotropin-releasing hormone modulates human hair follicle functions and plays a vital role in stimulating hair growth.TRH receptor activated by TRH activates various signal transduction pathways, which mediates the formation of two-second messenger molecules, inositol 1,4,5-trisphosphate, and 1,2-diacylglycerol. TRH expressed in pancreatic β cells aids in the positive regulation of insulin secretion.
Application
Thyrotropin-releasing hormone has been used as a media supplement to study its effects on stimulating the secretion of prolactin (PRL) from somatolactotroph GH3 cells by enzyme immunometric assay. It has also been used to study its effects on the regulation of energy homeostasis in the central nervous system (CNS) in response to essential amino-acid deprivation.
General description
Research area: Cell Signaling
Thyrotropin releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone, encoded by the gene mapped to human chromosome 3q13.3-q21. TRH is expressed in a variety of organs including central nervous system (CNS) and gastrointestinal tract, prostate, pancreas, thyroid, heart.
Thyrotropin releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone, encoded by the gene mapped to human chromosome 3q13.3-q21. TRH is expressed in a variety of organs including central nervous system (CNS) and gastrointestinal tract, prostate, pancreas, thyroid, heart.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
wgk
WGK 2
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
M Heinflink et al.
The Journal of clinical endocrinology and metabolism, 79(2), 650-652 (1994-08-01)
Activation of TRH receptors (TRH-R) stimulates a signal transduction pathway that leads to the formation of two second messenger molecules, inositol 1,4,5-trisphosphate and 1,2-diacylglycerol. It has been suggested that TRH may also cause an elevation of another second messenger, cAMP.
Thyrotropin-Releasing Hormone
Jackson I M D
The New England Journal of Medicine, 306, 145-155 (1982)
Erzsébet Gáspár et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(2), 393-403 (2009-10-15)
Thyrotropin-releasing hormone (TRH) is the most proximal component of the hypothalamic-pituitary-thyroid axis that regulates thyroid hormone synthesis. Since transcripts for members of this axis were detected in cultured normal human skin cells and since human hair follicles (HFs) respond to
Laura Domínguez et al.
Brain, behavior and evolution, 71(3), 231-246 (2008-04-03)
To improve knowledge of the peptidergic systems in the brain of amphibians we have conducted a comparative analysis of the distribution of TRH immunoreactive cell bodies and fibers in three species of urodeles. Fiber labeling was observed in all main
Elizabeth Hodge et al.
Journal of veterinary internal medicine, 33(5), 2272-2279 (2019-08-23)
The use of parallel dynamic tests to identify insulin dysregulation (ID) and pituitary pars intermedia dysfunction (PPID) in horses could have better diagnostic utility than measuring baseline hormone concentrations, if the tests do not alter diagnostic interpretation of one another.
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