P1319
促甲状腺素释放激素
≥98% (HPLC), powder
别名:
L-焦谷氨酰-L-组氨酰-L-脯氨酰胺, TRF, TRH, pGlu-His-Pro 酰胺, 促甲状腺素释放素
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关于此项目
经验公式（希尔记法）:
C16H22N6O4
化学文摘社编号:
分子量:
362.38
Beilstein:
770238
EC 号:
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.32
生物来源
human
方案
≥98% (HPLC)
表单
powder
分子量
362.38
储存条件
(Keep container tightly closed in a dry and well-ventilated place)
技术
activity assay: suitable
杂质
22.6-23.8% Nitrogen
51.9-54.1% carbon
溶解性
water: 25 mg/mL, cloudy, colorless to faintly yellow
储存温度
−20°C
SMILES字符串
NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]3CCC(=O)N3
InChI
1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
InChI key
XNSAINXGIQZQOO-SRVKXCTJSA-N
基因信息
human ... TRH(7200), TRHR(7201)
mouse ... Trhr(22045)
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Amino Acid Sequence
Glp-His-Pro-NH2
一般描述
Research area: Cell Signaling
Thyrotropin releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone, encoded by the gene mapped to human chromosome 3q13.3-q21. TRH is expressed in a variety of organs including central nervous system (CNS) and gastrointestinal tract, prostate, pancreas, thyroid, heart.
Thyrotropin releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone, encoded by the gene mapped to human chromosome 3q13.3-q21. TRH is expressed in a variety of organs including central nervous system (CNS) and gastrointestinal tract, prostate, pancreas, thyroid, heart.
应用
Thyrotropin-releasing hormone has been used as a media supplement to study its effects on stimulating the secretion of prolactin (PRL) from somatolactotroph GH3 cells by enzyme immunometric assay. It has also been used to study its effects on the regulation of energy homeostasis in the central nervous system (CNS) in response to essential amino-acid deprivation.
生化/生理作用
促进垂体前叶生成和分泌促甲状腺素 (TSH)。
Thyrotropin releasing hormone (TRH) stimulates production and secretion of thyrotropin (TSH) and prolactin from the anterior pituitary.
It also plays a vital role as a neurotransmitter and neuromodulator. Thyrotropin-releasing hormone modulates human hair follicle functions and plays a vital role in stimulating hair growth.TRH receptor activated by TRH activates various signal transduction pathways, which mediates the formation of two-second messenger molecules, inositol 1,4,5-trisphosphate, and 1,2-diacylglycerol. TRH expressed in pancreatic β cells aids in the positive regulation of insulin secretion.
It also plays a vital role as a neurotransmitter and neuromodulator. Thyrotropin-releasing hormone modulates human hair follicle functions and plays a vital role in stimulating hair growth.TRH receptor activated by TRH activates various signal transduction pathways, which mediates the formation of two-second messenger molecules, inositol 1,4,5-trisphosphate, and 1,2-diacylglycerol. TRH expressed in pancreatic β cells aids in the positive regulation of insulin secretion.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
Elizabeth Hodge et al.
Journal of veterinary internal medicine, 33(5), 2272-2279 (2019-08-23)
The use of parallel dynamic tests to identify insulin dysregulation (ID) and pituitary pars intermedia dysfunction (PPID) in horses could have better diagnostic utility than measuring baseline hormone concentrations, if the tests do not alter diagnostic interpretation of one another.
Vladimír Štrbák
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 50(1), 378-384 (2018-10-05)
Thyrotropin releasing hormone (TRH; pGlu-His-ProNH2) is expressed also in pancreatic β cells where it is colocalized in secretory granules with insulin. High perinatal changes of the TRH gene expression and TRH concentrations in rat pancreatic islets coincide with the perinatal
Advantage of double labeled in situ hybridization for detecting the effects of glucocorticoids on the mRNAs of protooncogenes and neural peptides (TRH) in cultured hypothalamic neurons.
Luo LG and Jackson IM
Brain Research. Brain Research Protocols, 4(2), 201-208 (1999)
Erzsébet Gáspár et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(2), 393-403 (2009-10-15)
Thyrotropin-releasing hormone (TRH) is the most proximal component of the hypothalamic-pituitary-thyroid axis that regulates thyroid hormone synthesis. Since transcripts for members of this axis were detected in cultured normal human skin cells and since human hair follicles (HFs) respond to
Laura Domínguez et al.
Brain, behavior and evolution, 71(3), 231-246 (2008-04-03)
To improve knowledge of the peptidergic systems in the brain of amphibians we have conducted a comparative analysis of the distribution of TRH immunoreactive cell bodies and fibers in three species of urodeles. Fiber labeling was observed in all main
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