P1319
促甲状腺素释放激素
≥98% (HPLC), powder
别名:
L-焦谷氨酰-L-组氨酰-L-脯氨酰胺, TRF, TRH, pGlu-His-Pro 酰胺, 促甲状腺素释放素
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关于此项目
经验公式（希尔记法）:
C16H22N6O4
化学文摘社编号:
分子量:
362.38
UNSPSC Code:
51111800
NACRES:
NA.32
PubChem Substance ID:
EC Number:
246-143-4
Beilstein/REAXYS Number:
770238
MDL number:
biological source
human
Quality Level
assay
≥98% (HPLC)
form
powder
mol wt
362.38
storage condition
(Keep container tightly closed in a dry and well-ventilated place)
technique(s)
activity assay: suitable
impurities
22.6-23.8% Nitrogen, 51.9-54.1% carbon
solubility
water: 25 mg/mL, cloudy, colorless to faintly yellow
storage temp.
−20°C
SMILES string
NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]3CCC(=O)N3
InChI
1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
InChI key
XNSAINXGIQZQOO-SRVKXCTJSA-N
Gene Information
human ... TRH(7200), TRHR(7201)
mouse ... Trhr(22045)
General description
Research area: Cell Signaling
Thyrotropin releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone, encoded by the gene mapped to human chromosome 3q13.3-q21. TRH is expressed in a variety of organs including central nervous system (CNS) and gastrointestinal tract, prostate, pancreas, thyroid, heart.
Thyrotropin releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone, encoded by the gene mapped to human chromosome 3q13.3-q21. TRH is expressed in a variety of organs including central nervous system (CNS) and gastrointestinal tract, prostate, pancreas, thyroid, heart.
Application
Thyrotropin-releasing hormone has been used as a media supplement to study its effects on stimulating the secretion of prolactin (PRL) from somatolactotroph GH3 cells by enzyme immunometric assay. It has also been used to study its effects on the regulation of energy homeostasis in the central nervous system (CNS) in response to essential amino-acid deprivation.
Biochem/physiol Actions
Thyrotropin releasing hormone (TRH) stimulates production and secretion of thyrotropin (TSH) and prolactin from the anterior pituitary.
It also plays a vital role as a neurotransmitter and neuromodulator. Thyrotropin-releasing hormone modulates human hair follicle functions and plays a vital role in stimulating hair growth.TRH receptor activated by TRH activates various signal transduction pathways, which mediates the formation of two-second messenger molecules, inositol 1,4,5-trisphosphate, and 1,2-diacylglycerol. TRH expressed in pancreatic β cells aids in the positive regulation of insulin secretion.
It also plays a vital role as a neurotransmitter and neuromodulator. Thyrotropin-releasing hormone modulates human hair follicle functions and plays a vital role in stimulating hair growth.TRH receptor activated by TRH activates various signal transduction pathways, which mediates the formation of two-second messenger molecules, inositol 1,4,5-trisphosphate, and 1,2-diacylglycerol. TRH expressed in pancreatic β cells aids in the positive regulation of insulin secretion.
促进垂体前叶生成和分泌促甲状腺素 (TSH)。
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
wgk
WGK 2
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
Vladimír Štrbák
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 50(1), 378-384 (2018-10-05)
Thyrotropin releasing hormone (TRH; pGlu-His-ProNH2) is expressed also in pancreatic β cells where it is colocalized in secretory granules with insulin. High perinatal changes of the TRH gene expression and TRH concentrations in rat pancreatic islets coincide with the perinatal
Advantage of double labeled in situ hybridization for detecting the effects of glucocorticoids on the mRNAs of protooncogenes and neural peptides (TRH) in cultured hypothalamic neurons.
Luo LG and Jackson IM
Brain Research. Brain Research Protocols, 4(2), 201-208 (1999)
Thyrotropin-Releasing Hormone
Jackson I M D
The New England Journal of Medicine, 306, 145-155 (1982)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P1319-250MG | 04061834354536 |
| P1319-50MG | 04061834354543 |
| P1319-1G | 04061826153178 |