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Merck
CN

P1372

帕罗西汀 马来酸盐

≥98% (HPLC), Selective serotonin reuptake inhibitor, solid

别名:

(3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine maleate salt, BRL-29060, FG-7051

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关于此项目

经验公式（希尔记法）:
C19H20FNO3 · C4H4O4
化学文摘社编号:
64006-44-6
分子量:
445.44
MDL编号:
MFCD01742665
UNSPSC代码:
12352200
PubChem化学物质编号:
329820091
NACRES:
NA.77

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产品名称

帕罗西汀 马来酸盐, ≥98% (HPLC), solid

质量水平

100

方案

≥98% (HPLC)

表单

solid

颜色

white to off-white

溶解性

DMSO: ~12 mg/mL
H2O: insoluble

创始人

GlaxoSmithKline

储存温度

2-8°C

SMILES字符串

OC(=O)\C=C/C(O)=O.Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3

InChI

1S/C19H20FNO3.C4H4O4/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;5-3(6)1-2-4(7)8/h1-6,9,14,17,21H,7-8,10-12H2;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,17-;/m0./s1

InChI key

AEIUZSKXSWGSRU-QXGDPHCHSA-N

基因信息

human ... SLC6A4(6532)

相关类别

生化/生理作用

Paroxetine is a strong cytochrome P450 2D6 isotype (CYP2D6) inhibitor, which reduces the effectiveness of tamoxifen. This phenylpiperidine derivative inhibits clozapine metabolism. Paroxetine is used to treat social phobia, obsessive-compulsive disorder and panic disorder. It is also used to treat the premenstrual dysphoric disorder, post-traumatic stress disorder and chronic headache.
Paroxetine maleate is a selective serotonin reuptake inhibitor; antidepressant.

特点和优势

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

Sold with the permission of Glaxo­Smith­Kline

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000356719
0000356719
0000355449
0000355449
0000226620

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访问文档库

Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (2015)
Supportive Oncology E-Book (2011)
Paroxetine: a review
Bourin M, et al.
Cns Drug Reviews, 7(1), 25-47 (2001)
Wei-Rong Lin et al.
Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 32(12), 1063-1069 (2013-01-11)
To compare the differences in the efficacy on agitated depression among the alliance therapy of acupuncture and seroxat, the alliance therapy of electroacupuncture and seroxat and the simple application of seroxat. One hundred and two cases were randomized into a
Yukiko Mine et al.
Journal of pharmacological sciences, 121(1), 58-66 (2012-12-22)
Although selective serotonin reuptake inhibitors (SSRIs) are widely used to treat depression, they frequently cause gastrointestinal adverse effects, such as nausea and emesis. In the present study, we investigated the anti-emetic effect of mosapride, a 5-HT(4) receptor agonist, on SSRIs-induced
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