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P1372

帕罗西汀马来酸盐

Name: 帕罗西汀 马来酸盐
Brand: SIGMA

≥98% (HPLC), Selective serotonin reuptake inhibitor, solid

别名:

(3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine maleate salt, BRL-29060, FG-7051

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关于此项目

经验公式（希尔记法）:

C₁₉H₂₀FNO₃ · C₄H₄O₄

化学文摘社编号:

64006-44-6

分子量:

445.44

UNSPSC Code:

12352200

PubChem Substance ID:

329820091

NACRES:

NA.77

MDL number:

MFCD01742665

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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产品名称

帕罗西汀马来酸盐, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: ~12 mg/mL, H₂O: insoluble

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

OC(=O)\C=C/C(O)=O.Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3

InChI

1S/C19H20FNO3.C4H4O4/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;5-3(6)1-2-4(7)8/h1-6,9,14,17,21H,7-8,10-12H2;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,17-;/m0./s1

InChI key

AEIUZSKXSWGSRU-QXGDPHCHSA-N

Gene Information

human ... SLC6A4(6532)

Biochem/physiol Actions

Paroxetine is a strong cytochrome P450 2D6 isotype (CYP2D6) inhibitor, which reduces the effectiveness of tamoxifen. This phenylpiperidine derivative inhibits clozapine metabolism. Paroxetine is used to treat social phobia, obsessive-compulsive disorder and panic disorder. It is also used to treat the premenstrual dysphoric disorder, post-traumatic stress disorder and chronic headache.

Paroxetine maleate is a selective serotonin reuptake inhibitor; antidepressant.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold with the permission of GlaxoSmithKline

pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000356719

0000355449

0000226620

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Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (2015)

Supportive Oncology E-Book (2011)

Paroxetine: a review

Bourin M, et al.

Cns Drug Reviews, 7(1), 25-47 (2001)

[Global improvement in agitated depression treated with the alliance therapy of acupuncture and seroxat and the observation of the quality of life].

Wei-Rong Lin et al.

Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 32(12), 1063-1069 (2013-01-11)

To compare the differences in the efficacy on agitated depression among the alliance therapy of acupuncture and seroxat, the alliance therapy of electroacupuncture and seroxat and the simple application of seroxat. One hundred and two cases were randomized into a

Double, suicidal intoxication with hydroxycarbamide--a case report.

Wojciech Waldman et al.

Przeglad lekarski, 69(8), 587-588 (2012-12-19)

Hydroxycarbamide (HCB), also known as hydroxyurea, is an urea derivative used mainly as antineoplastic and antisickling agent. We described a 31 yrs. female, with essential thrombocythemia, who was admitted to our clinic because of double suicidal ingestion of hydroxycarbamide. First

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全球贸易项目编号

货号	GTIN
P1372-10MG	04061833621707
P1372-50MG	04061833621714

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