P148
4α-佛波醇12-十四酸酯13-乙酸酯
solid, ≥95% (TLC)
别名:
4α-PMA
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C36H56O8
化学文摘社编号:
分子量:
616.83
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
产品名称
4α-佛波醇12-十四酸酯13-乙酸酯, solid, ≥95% (TLC)
InChI
1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34+,35-,36-/m1/s1
SMILES string
CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(C)=O
InChI key
PHEDXBVPIONUQT-LQLWEASQSA-N
assay
≥95% (TLC)
form
solid
color
white
solubility
H2O: ~2 μM
DMSO: soluble
ethanol: soluble
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
蛋白质激酶C佛波醇酯活化阴性对照。
Disclaimer
光敏性
General description
本品虽然具有水溶性，但建议先将其溶解于与水混溶的有机溶剂中，然后在水性介质中稀释至工作浓度。
Packaging
玻璃安瓿封装。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Izabela Woclawek-Potocka et al.
Prostaglandins & other lipid mediators, 79(3-4), 287-297 (2006-05-02)
Corpus luteum (CL) is a reproductive gland that plays a crucial endocrine role in the regulation of the estrous cycle, fertility, and pregnancy in cattle. The main function of CL is secretion of progesterone (P4), an important hormone for establishment
B L Van Duuren et al.
Cancer research, 39(7 Pt 1), 2644-2646 (1979-07-01)
4a alpha-Phorbol-9,9a-didecanoate, 4a alpha-phorbol-9-myristate-9a-acetate, and phorbol-9-myristate-9a-acetate-3-aldehyde were tested for skin tumor-promoting activity by using 7,12-dimethylbenz(a)anthracene as the initiating agent. There were 30 female ICR/Ha mice/group, and tests were continued for 434 to 461 days. 4a alpha-Phorbol-9,9a-didecanoate and 4a alpha-phorbol-9-myristate-9a-acetate were
Amani Batarseh et al.
Biochemistry, 47(48), 12886-12899 (2008-11-04)
Translocator protein (TSPO) is an 18-kDa cholesterol-binding protein that is expressed at high levels in steroid synthesizing and several cancer cells where it is involved in steroidogenesis and cell proliferation, respectively. The factors regulating Tspo expression are unknown. We analyzed
Feng Xu et al.
British journal of pharmacology, 140(2), 413-421 (2003-09-13)
1. We investigated whether protein kinase C (PKC) activation stimulates Ca2+ entry in HEK 293 cells transfected with human TRPV4 cDNA and loaded with fura-2. 2. Phorbol 12-myristate 13-acetate (PMA), a PKC-activating phorbol ester, increased the intracellular Ca2+ concentration ([Ca2+]i)
R A Nichols et al.
Journal of neurochemistry, 48(2), 615-621 (1987-02-01)
Neurotransmitter release from rat brain synaptosomes was measured following pretreatment with various phorbol esters. Ca2+-dependent, evoked neurotransmitter release was increased by phorbol esters that were active in stimulating protein kinase C. Protein kinase C activation was demonstrated by increased incorporation
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持