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Merck
CN

P152

S(–)-Pindolol

solid

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关于此项目

经验公式（希尔记法）:
C14H20N2O2
化学文摘社编号:
26328-11-0
分子量:
248.32
UNSPSC Code:
12352202
PubChem Substance ID:
24278026
MDL number:
MFCD00153863
Form:
solid
Quality level:
100

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InChI

1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3/t11-/m0/s1

SMILES string

CC(C)NC[C@H](O)COc1cccc2[nH]ccc12

InChI key

JZQKKSLKJUAGIC-NSHDSACASA-N

form

solid

optical activity

[α]23/D −4.38°, c = 1% in methanol(lit.)

color

white

solubility

0.1 M NaOH: 0.2 mg/mL, methanol: 18 mg/mL, 0.1 M HCl: 20 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 3.4 mg/mL, H2O: insoluble

originator

Novartis

Quality Level

100

Gene Information

human ... ADRB1(153), HTR1A(3350), HTR1B(3351)

Biochem/physiol Actions

β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator. Active enantiomer of pindolol.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number
082K4601

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M J Millan et al.
Neuropharmacology, 38(6), 909-912 (1999-08-28)
(-)-Pindolol (2.5-20.0 mg/kg, s.c.) markedly increased extracellular levels of dopamine (DA) and noradrenaline (NA) in single dialysate samples of the frontal cortex (FCX) of freely-moving rats. This action was specific inasmuch as serotonin (5-HT) levels were not significantly modified. In
D J Watkins et al.
Journal of the autonomic nervous system, 60(1-2), 12-16 (1996-08-27)
The nodose ganglion contains the cell bodies of afferent nerves which convey predominantly sensory information from the viscera to the central nervous system (CNS). Autoradiographic studies show binding sites for beta-adrenoceptor ligands are present on sections of the rat nodose
J Ichikawa et al.
Brain research, 842(2), 445-451 (1999-10-20)
Serotonin (5-hydroxytryptamine, 5-HT)(1A) receptor agonism and 5-HT(2A) receptor antagonism are components in the action of some of the recently developed antipsychotic drugs, e.g., clozapine and ziprasidone. However, studies of the role of 5-HT(1A) receptor agonism in the ability of these
C A Fornal et al.
The Journal of pharmacology and experimental therapeutics, 291(1), 229-238 (1999-09-22)
Clinical studies have shown that pindolol can enhance the effects of antidepressant drugs, presumably by acting as an antagonist at somatodendritic 5-hydroxytryptamine (5-HT)(1A) autoreceptors, which regulate the firing rate of central serotonergic neurons. The current study characterized the action of
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the

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