P154
吡那地尔 一水合物
powder
别名:
(±)-N-氰基-N′-4-吡啶-N″-(1,2,2-三甲基丙基)胍 一水合物
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选择尺寸
关于此项目
经验公式（希尔记法）:
C13H19N5 · H2O
化学文摘社编号:
分子量:
263.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
262-294-9
MDL number:
产品名称
吡那地尔 一水合物, powder
InChI key
AFJCNBBHEVLGCZ-UHFFFAOYSA-N
InChI
1S/C13H19N5.H2O/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11;/h5-8,10H,1-4H3,(H2,15,16,17,18);1H2
SMILES string
O.CC(N\C(Nc1ccncc1)=N\C#N)C(C)(C)C
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL, clear
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 40 mg/mL
Quality Level
Gene Information
human ... ABCC9(10060), KCNJ11(3767)
mouse ... Kcnj11(16514)
rat ... Kcna1(24520), Kcnj1(24521), Kcnj11(83535), Kcnj5(29713), Kcnj8(25472)
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Application
使用吡那地尔：
- 通过注入左前降支用于复极化研究
- 在心室肌细胞中诱导ATP敏感性K+ (KATP)电流，用于电生理检查
- 作为KATP开启剂来治疗心肌细胞
Biochem/physiol Actions
K+ 通道激活剂；降压药。
吡那地尔是一种KATP通道激动剂。它可通过防止线粒体膜电位的丢失来保护心肌细胞。它可以防止缺氧/复氧损伤中半胱天冬酶3的激活。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Milla Mikkola et al.
Stem cells and development, 22(5), 707-716 (2012-10-31)
Lectins are carbohydrate-binding proteins, which occur ubiquitously in nature and are abundant in all living organisms from bacteria to mammals. They have several biological functions among which cell adhesion is well known and characterized. Based on the characterization of the
Asami Mori et al.
European journal of pharmacology, 669(1-3), 94-99 (2011-08-30)
The large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels modulate the retinal vascular tone, but question of whether the impairment of the channel function contributes to abnormalities of retinal circulation has not yet been completely elucidated. The purpose of this study was to
Jun-Yih Chen et al.
Shock (Augusta, Ga.), 38(2), 203-212 (2012-05-12)
Alterations in the activity of vascular K channels are commonly associated with abnormalities in cerebral vascular function after subarachnoid hemorrhage (SAH). Subarachnoid hemorrhage-induced vasospasm remains incompletely understood; nevertheless, activation of K channels may be of benefit in relieving spastic constriction.
Protective actions of epoxyeicosatrienoic acid: dual targeting of cardiovascular PI3K and KATP channels
Bodiga S, et al.
Journal of Molecular and Cellular Cardiology, 46(6), 978-988 (2009)
Electrophysiological analyses of transgenic mice overexpressing KCNJ8 with S422L mutation in cardiomyocytes
Watanabe Y, et al.
Journal of Pharmacological Sciences, 135(1), 37-43 (2017)
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