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关于此项目
经验公式(希尔记法):
C13H19N5 · H2O
化学文摘社编号:
分子量:
263.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
262-294-9
MDL number:
form
powder
Quality Level
color
white to beige
solubility
DMSO: 15 mg/mL, clear, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 40 mg/mL
SMILES string
O.CC(N\C(Nc1ccncc1)=N\C#N)C(C)(C)C
InChI
1S/C13H19N5.H2O/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11;/h5-8,10H,1-4H3,(H2,15,16,17,18);1H2
InChI key
AFJCNBBHEVLGCZ-UHFFFAOYSA-N
Gene Information
human ... ABCC9(10060), KCNJ11(3767)
mouse ... Kcnj11(16514)
rat ... Kcna1(24520), Kcnj1(24521), Kcnj11(83535), Kcnj5(29713), Kcnj8(25472)
Application
使用吡那地尔:
- 通过注入左前降支用于复极化研究
- 在心室肌细胞中诱导ATP敏感性K+ (KATP)电流,用于电生理检查
- 作为KATP开启剂来治疗心肌细胞
Biochem/physiol Actions
吡那地尔是一种KATP通道激动剂。它可通过防止线粒体膜电位的丢失来保护心肌细胞。它可以防止缺氧/复氧损伤中半胱天冬酶3的激活。
K+ 通道激活剂;降压药。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Jing Xu et al.
Journal of cardiovascular pharmacology, 59(6), 514-522 (2012-02-22)
We investigated the beneficial effect of pinacidil pretreatment on vascular reactivity, calcium sensitivity, and animal survival after hemorrhagic shock, its relationship to protein kinase Cα (PKCα), protein kinase Cε (PKCε), and adenosine. Using hemorrhagic shock rats, the protective effects of
Ivana Barbaric et al.
Cryobiology, 63(3), 298-305 (2011-10-27)
Human embryonic stem cells (hESCs) can be maintained as undifferentiated cells in vitro and induced to differentiate into a variety of somatic cell types. Thus, hESCs provide a source of differentiated cell types that could be used to replace diseased
Jeanne G van der Waal et al.
Frontiers in physiology, 12, 737609-737609 (2021-11-09)
Background: The detection and localization of electrophysiological substrates currently involve invasive cardiac mapping. Electrocardiographic imaging (ECGI) using the equivalent dipole layer (EDL) method allows the noninvasive estimation of endocardial and epicardial activation and repolarization times (AT and RT), but the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML1024-5MG | 04061833224694 |
| SML1024-25MG | 04061833224687 |
