P1620
Anti-PRMT1 antibody, Mouse monoclonal
clone PRMT1-171, purified from hybridoma cell culture
别名:
Anti-Protein-Arginine Methyl Transferase 1
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关于此项目
Conjugate:
unconjugated
Clone:
PRMT1-171, monoclonal
Application:
ELISA (i), IP, WB
Citations:
9
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
PRMT1-171, monoclonal
form
buffered aqueous solution
mol wt
antigen ~42 kDa
species reactivity
mouse, chicken, bovine, human, canine, hamster, monkey, rat
concentration
~2 mg/mL
technique(s)
immunoprecipitation (IP): suitable, indirect ELISA: suitable, western blot: 2 μg/mL using whole cell extract of 293T cells
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PRMT1(3276)
General description
Protein arginine methyltransferase 1 (PRMT1) gene is localized on human chromosome 19q13.33. It is part of the type I PRMT family.
Immunogen
full length PRMT1. Does not cross-react with PRMT2, 3, 4, and 5.
Application
Anti-PRMT1 antibody, Mouse monoclonal has been used for Immunofluorescence and Western Blotting.
Biochem/physiol Actions
Does not cross-react with PRMT2, 3, 4, and 5.
Protein arginine methyltransferase 1 (PRMT1) is crucial for the formation of asymmetric dimethylarginine. It can methylate Twist-1, a transcription factor. The protein also methylates histones and thus modulates transcription and protein activity. PRMT1 is involved in epithelial-mesenchymal transition and may have a role in cancer.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2-8 C for up to one month. For prolonged storage, freeze in working aliquots at 20 C. Repeated freezing and thawing, or storage in frost-free freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
PRMT1 Is a Novel Regulator of Epithelial-Mesenchymal-Transition in Non-small Cell Lung Cancer.
Avasarala S, et al.
The Journal of Biological Chemistry, 290(21), 13479-13489 (2015)
PRMT1 promotes glucose toxicity-induced β cell dysfunction by regulating the nucleo-cytoplasmic trafficking of PDX-1 in a FOXO1-dependent manner in INS-1 cells.
Lv L, et al.
Endocrine, 49(3), 669-682 (2015)
Common fusion transcripts identified in colorectal cancer cell lines by high-throughput RNA sequencing.
Nome T, et al.
Translational Oncology, 6(5), 546-IN5-546-IN5 (2013)
PRMT1-mediated arginine methylation controls ATXN2L localization.
Kaehler C, et al.
Experimental Cell Research, 334(1), 114-125 (2015)
Li Liu et al.
Scientific reports, 6, 21810-21810 (2016-02-26)
Protein arginine methyltransferase 1 (PRMT1) catalyzes methylation of histones and other cellular proteins, and thus regulates gene transcription and protein activity. In antigen-induced pulmonary inflammation (AIPI) PRMT1 was up-regulated in the epithelium, while in chronic AIPI, increased PRMT1 shifted to
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