P1639
棒曲霉素
≥98.0% (HPLC)
别名:
4-羟基-4H-呋[3,2-c]吡喃-2(6H)-酮
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关于此项目
经验公式（希尔记法）:
C7H6O4
化学文摘社编号:
分子量:
154.12
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
EC Number:
205-735-2
Beilstein/REAXYS Number:
149675
MDL number:
Quality Segment
assay
≥98.0% (HPLC)
form
powder
solubility
water: 9-11 mg/mL
antibiotic activity spectrum
fungi
mode of action
cell membrane | interferes
storage temp.
−20°C
SMILES string
OC1OCC=C2OC(=O)C=C12
InChI
1S/C7H6O4/c8-6-3-4-5(11-6)1-2-10-7(4)9/h1,3,7,9H,2H2
InChI key
ZRWPUFFVAOMMNM-UHFFFAOYSA-N
General description
Patulin is a mycotoxin produced by a variety of molds, such as, Aspergillus and Penicillium. It is commonly found in apples. It is used as an inhibitor of potassium uptake and as an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase and to induce intra- and intermolecular protein crosslinking.
Application
Patulin has been used:
- to study patulin contamination of bottled wine
- in DNA-damaging activity of patulin in Escherichia coli
- in molecular cloning and functional characterization of two CYP619 cytochrome P450s involved in biosynthesis of patulin in Aspergillus clavatus
Biochem/physiol Actions
Mycotoxin with anti-bacterial, potassium uptake inhibitory, and possibly carcinogenic activities. It is used as an inhibitor of potassium uptake and as an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase and to induce intra- and intermolecular protein crosslinking.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Skin Irrit. 2
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
ppe
Eyeshields, Gloves