P1639
棒曲霉素
≥98.0% (HPLC)
别名:
4-羟基-4H-呋[3,2-c]吡喃-2(6H)-酮
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关于此项目
经验公式（希尔记法）:
C7H6O4
化学文摘社编号:
分子量:
154.12
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
EC Number:
205-735-2
Beilstein/REAXYS Number:
149675
MDL number:
InChI
1S/C7H6O4/c8-6-3-4-5(11-6)1-2-10-7(4)9/h1,3,7,9H,2H2
InChI key
ZRWPUFFVAOMMNM-UHFFFAOYSA-N
SMILES string
OC1OCC=C2OC(=O)C=C12
assay
≥98.0% (HPLC)
form
powder
solubility
water: 9-11 mg/mL
antibiotic activity spectrum
fungi
mode of action
cell membrane | interferes
storage temp.
−20°C
Quality Level
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General description
Patulin is a mycotoxin produced by a variety of molds, such as, Aspergillus and Penicillium. It is commonly found in apples. It is used as an inhibitor of potassium uptake and as an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase and to induce intra- and intermolecular protein crosslinking.
Application
Patulin has been used:
- to study patulin contamination of bottled wine
- in DNA-damaging activity of patulin in Escherichia coli
- in molecular cloning and functional characterization of two CYP619 cytochrome P450s involved in biosynthesis of patulin in Aspergillus clavatus
Biochem/physiol Actions
Mycotoxin with anti-bacterial, potassium uptake inhibitory, and possibly carcinogenic activities. It is used as an inhibitor of potassium uptake and as an inducer of ion flux across cell membranes, potentially involving Na+-K+ dependent ATPase and to induce intra- and intermolecular protein crosslinking.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Skin Irrit. 2
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
ppe
Eyeshields, Gloves
法规信息
涉药品监管产品
此项目有
Effects of various lactones and related compounds on cation transfer in incubated cold-stored human erythrocytes.
J B KAHN
The Journal of pharmacology and experimental therapeutics, 121(2), 234-251 (1957-10-01)
Nikita Malhotra et al.
International journal of cardiology, 197, 318-325 (2015-07-08)
A therapeutic window in antiplatelet treatment has been associated with concurrent lowering of bleeding and ischemic risks. Prasugrel and ticagrelor provide potent platelet inhibition, but may increase bleeding. No study has evaluated a personalized therapy with selective use of novel
Birkinshaw, M., et al.
Lancet, 245, 625-625 (1943)
Marieke Vansteelandt et al.
Fungal biology, 116(9), 954-961 (2012-09-08)
Genus Penicillium represents an important fungal group regarding to its mycotoxin production. Secondary metabolomes of eight marine-derived strains belonging to subgenera Furcatum and Penicillium were investigated using dereplication by liquid chromatography (LC)-Diode Array Detector (DAD)-mass spectrometry (MS)/MS. Each strain was
Alicia Rodríguez et al.
International journal of food microbiology, 155(1-2), 10-18 (2012-02-14)
A multiplex real-time PCR (qPCR) method to quantify aflatoxin, ochratoxin A (OTA) and patulin producing molds in foods was developed. For this, the primer pairs F/R-omt, F/R-npstr and F/R-idhtrb and the TaqMan probes, OMTprobe, NPSprobe and IDHprobe targeting the omt-1
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