P1761
反式-2-苯基环丙胺 半硫酸盐
别名:
反苯环丙胺
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关于此项目
线性分子式:
C9H11N · 1/2H2SO4
化学文摘社编号:
分子量:
182.23
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
236-807-1
MDL number:
InChI key
BKPRVQDIOGQWTG-KAVFMPKWSA-N
InChI
1S/2C9H11N.H2O4S/c2*10-9-6-8(9)7-4-2-1-3-5-7;1-5(2,3)4/h2*1-5,8-9H,6,10H2;(H2,1,2,3,4)/t2*8-,9+;/m11./s1
SMILES string
OS(O)(=O)=O.N[C@H]1C[C@@H]1c2ccccc2.N[C@H]3C[C@@H]3c4ccccc4
assay
≥98% (perchloric acid titration)
form
powder
solubility
water: 0.0333 g/mL, clear to slightly hazy, colorless to faintly yellow
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
非选择性 MAO-A/B 抑制剂。
trans-2-Phenylcyclopropylamine acts as an inhibitor of lysine-specific demethylase 1 (LSD1). It exhibits anti-depressant and anxiolytic activity. Tranylcypromine shows therapeutic effects against mood and anxiety issues. It also exhibits anti-osteoclastogenic effects through monoamine oxidase-A (MAO-A). Tranylcypromine may play a role in bone remodeling in mice.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Zhuochao Liu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(9), 9828-9841 (2019-07-11)
Identification of anti-osteoclastogenic agents is important for the treatment of bone loss diseases that feature excessive osteoclast (OC) activity and bone resorption. Tranylcypromine (TCP), an irreversible inhibitor of monoamine oxidase (MAO), has been used as an antidepressant and anxiolytic agent
Maojun Yang et al.
Biochemistry, 46(27), 8058-8065 (2007-06-16)
Histone modifications, such as acetylation and methylation, are important epigenetic marks that regulate diverse biological processes that use chromatin as the template, including transcription. Dysregulation of histone acetylation and methylation leads to the silencing of tumor suppressor genes and contributes
Elisa Maria Rieckhoff et al.
Current biology : CB, 30(24), 4973-4983 (2020-11-21)
Cellular organelles such as the mitotic spindle adjust their size to the dimensions of the cell. It is widely understood that spindle scaling is governed by regulation of microtubule polymerization. Here, we use quantitative microscopy in living zebrafish embryos and
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