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Merck
CN

P1793

匹莫齐特

≥98% (TLC), powder, D₂ dopamine receptor antagonist

别名:

1-[1-[4,4-双（4-氟苯基）丁基]-4-哌啶基]-1,3-二氢-2H-苯并咪唑-2-酮

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关于此项目

经验公式（希尔记法）:
C28H29F2N3O
化学文摘社编号:
2062-78-4
分子量:
461.55
NACRES:
NA.77
PubChem Substance ID:
24277923
UNSPSC Code:
12352200
EC Number:
218-171-7
MDL number:
MFCD00055081

主要文件

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产品名称

匹莫齐特,

InChI key

YVUQSNJEYSNKRX-UHFFFAOYSA-N

InChI

1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)

SMILES string

Fc1ccc(cc1)C(CCCN2CCC(CC2)N3C(=O)Nc4ccccc34)c5ccc(F)cc5

form

powder

solubility

DMSO: 18 mg/mL(lit.)
chloroform: 5 mg/mL
H2O: insoluble(lit.)

originator

Teva

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... ABCB1(5243), CACNA1G(8913), CYP3A4(1576), DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), HTR2A(3356), HTR7(3363), KCNH1(3756), KCNH2(3757), OPRD1(4985)
mouse ... Abcb1a(18671), Abcb1b(18669)
rat ... Scnn1g(24768)

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Features and Benefits

该化合物由 Teva 开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表，请点击此处。
该化合物在受体分类和信号转导手册的环核苷酸门控（CNG）和超极化激活的环核苷酸门控（HCN）通道页面上有详细描述。想要浏览手册的其他页面， 请单击此处。
该化合物是环核苷酸研究的特色产品。 点击此处 ，发现更多特色环核苷酸产品。。在 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。

Biochem/physiol Actions

D 2 多巴胺受体拮抗剂；与克隆的 5-HT 7 受体高亲和力结合；Ca 2 + 通道拮抗剂；抗精神病药

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000463569
0000463567
0000463569
0000463567
0000428602

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Cancers, 14 (2022)
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The Cochrane database of systematic reviews, (2)(2), CD006996-CD006996 (2009-04-17)
Neuroleptic drugs with potent D-2 receptor blocking properties have been the traditional treatment for tics caused by Tourette Syndrome. Pimozide is the most studied of these. Use of these medications is declining because of concerns about side effects, and new
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