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Merck
CN

P183

(+)-PD 128,907 hydrochloride

>97%, solid

别名:

(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride

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关于此项目

经验公式(希尔记法):
C14H19NO3 · HCl
化学文摘社编号:
分子量:
285.77
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Assay:
>97%
Form:
solid
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assay

>97%

form

solid

color

off-white

solubility

ethanol: >10 mg/mL, DMSO: 18 mg/mL, H2O: 9 mg/mL

SMILES string

Cl.CCCN1CCO[C@H]2[C@H]1COc3ccc(O)cc23

InChI

1S/C14H19NO3.ClH/c1-2-5-15-6-7-17-14-11-8-10(16)3-4-13(11)18-9-12(14)15;/h3-4,8,12,14,16H,2,5-7,9H2,1H3;1H/t12-,14-;/m1./s1

InChI key

DCFXOTRONMKUJB-QMDUSEKHSA-N

Gene Information

human ... DRD3(1814)

Biochem/physiol Actions

Selective D3 dopamine receptor agonist.

Legal Information

Manufactured and sold with the permission of Warner-Lambert Company.

Disclaimer

Light sensitive

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Assessment of cocaine-like discriminative stimulus effects of dopamine D3 receptor ligands.
Acri, et al.
European Journal of Pharmacology, 281 (1995)
F Sautel et al.
Neuroreport, 6(2), 329-332 (1995-01-26)
The functional potency of a series of dopamine agonists for increasing mitogenesis, measured by incorporation of [3H]thymidine, was established in transfected cell lines expressing human D2 or D3 receptors. The functional selectivity of agonists markedly differs from their binding selectivity.
H A DeWald et al.
Journal of medicinal chemistry, 33(1), 445-450 (1990-01-01)
The dopamine agonist profile of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol (16a) and its enantiomers (16b-c) was examined. Racemic 16a exhibited moderate affinity for the dopamine (DA) D2 receptor labeled with the DA antagonist ligand [3H]haloperidol and moderate in vivo activity; it attenuated gamma-butyrolactone-stimulated
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the

全球贸易项目编号

货号GTIN
P183-25MG04061832272894
P183-5MG04061832092560

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