P1867
纤溶酶 来源于人类血浆
lyophilized powder, ≥2.0 units/mg protein
别名:
纤溶酶
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
eCl@ss:
42030239
EC Number:
232-640-3
NACRES:
NA.54
MDL number:
Specific activity:
≥2.0 units/mg protein
General description
纤溶酶作为纤维蛋白溶解级联的关键酶起作用，并且在炎症过程中也是重要的。
Application
通过来自尿激酶活化的人血浆的亲和色谱法在研究中分离了纤溶酶和抑制剂之间的复合物。 它还被用于研究纤溶酶和胰凝乳蛋白酶激活人上皮钠通道（ENaC）的研究。
Biochem/physiol Actions
它会被α2-抗纤溶酶抑制并且阻断其与纤维蛋白的相互作用。 它消化细胞质蛋白α突触核蛋白的N-末端区域，防止其被周围细胞摄取。
纤溶酶在赖氨酸和精氨酸残基的羧基侧表现出优先的切割，其选择性高于胰蛋白酶。它可将聚合纤维蛋白转化为可溶性产物。
最适 pH：8.5
pH 7.5：约 40％ 的最大活性，约 50％ 的最大活性
最适温度：37°C，于 56°C 快速失活
最适 pH：8.5
pH 7.5：约 40％ 的最大活性，约 50％ 的最大活性
最适温度：37°C，于 56°C 快速失活
Packaging
包装尺寸基于蛋白质含量
Physical form
含有磷酸钠和海藻糖的冻干粉。
Other Notes
一个单元将在 pH7.5，37℃ 下，每分钟从 D-Val-Leu-Lys-p-硝基苯胺生产 μmole 对硝基苯胺。
Disclaimer
仅供研究使用。在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
高风险级别生物产品--人源产品
此项目有
S Müllertz et al.
The Biochemical journal, 159(3), 545-553 (1976-12-01)
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PloS one, 16(3), e0248431-e0248431 (2021-03-16)
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To characterize the levels of active ocriplasmin over a period of ascending time points (range, 5 minutes to 7 days) from intravitreal injection of a 125-μg dose to sampling. During this 7-week controlled, open-label, phase 2 study, a single intravitreal
Silke Haerteis et al.
The Journal of general physiology, 140(4), 375-389 (2012-09-12)
Proteolytic activation of the epithelial sodium channel (ENaC) involves cleavage of its γ subunit in a critical region targeted by several proteases. Our aim was to identify cleavage sites in this region that are functionally important for activation of human
Sara Raimondi et al.
The Journal of biological chemistry, 295(33), 11379-11387 (2020-06-24)
Systemic amyloidosis caused by extracellular deposition of insoluble fibrils derived from the pathological aggregation of circulating proteins, such as transthyretin, is a severe and usually fatal condition. Elucidation of the molecular pathogenic mechanism of the disease and discovery of effective
实验方案
Enzymatic Assay of Plasmin with D-Val-Leu-Lys-p-Nitroanilide Dihydrochloride
Enzymatic Assay of Plasmin with D-Val-Leu-Lys-p-Nitroanilide Dihydrochloride
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P1867-1500UG | 04061834357001 |
| P1867-750UG | 04061834357087 |
| P1867-500UG | 04061834357070 |
| P1867-150UG | 04061834357063 |
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