P1941
聚（D,L-丙交酯-co-乙交酯）
lactide:glycolide (75:25), mol wt 66,000-107,000
别名:
LACTEL® B6007-1, PLGA
一般描述
本品是一种无定形固体，转变温度（Tg）范围为45-50℃。它可溶于大多数有机溶剂，如二氯甲烷、四氢呋喃、乙酸乙酯、丙酮、氯仿和六氟异丙醇。
应用
聚(D,L-丙交酯-CO-乙交酯)是一种合成氨基酸，已可用于递送大分子治疗药物。
特点和优势
控释生物活性剂、缝线和可生物吸收植入器件。
外形
具有生物相容性且可生物降解的聚合物。
法律信息
Lactel is a registered trademark of Evonik Corp
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Fabrication of amorphous strontium polyphosphate microparticles that induce mineralization of bone cells in vitro and in vivo
Werner E.G.Muller
Acta Biomaterialia, 50, 89-101 (2017)
Robert M Stefani et al.
Acta biomaterialia, 102, 326-340 (2019-12-06)
Articular cartilage defects are a common source of joint pain and dysfunction. We hypothesized that sustained low-dose dexamethasone (DEX) delivery via an acellular osteochondral implant would have a dual pro-anabolic and anti-catabolic effect, both supporting the functional integrity of adjacent
Maria Kirzhner et al.
Ophthalmology, 120(6), 1300-1304 (2013-02-13)
To compare wrapped and polymer-coated hydroxyapatite implants in children undergoing primary enucleation with no adjuvant therapies. Retrospective, interventional cohort study. All children undergoing primary enucleation without adjuvant therapies between 1999 and 2009 at a tertiary pediatric cancer hospital. Review and
Igor Jeroukhimov et al.
Journal of the American College of Surgeons, 218(1), 102-107 (2013-11-12)
Chronic pain after inguinal hernia repair occurs in 16% to 62% of patients. The underlying mechanism probably involves sensory nerve damage and abnormal healing that might be influenced by the materials chosen for the procedure. We hypothesize that nonabsorbable sutures
Daniel R Getts et al.
Nature biotechnology, 30(12), 1217-1224 (2012-11-20)
Aberrant T-cell activation underlies many autoimmune disorders, yet most attempts to induce T-cell tolerance have failed. Building on previous strategies for tolerance induction that exploited natural mechanisms for clearing apoptotic debris, we show that antigen-decorated microparticles (500-nm diameter) induce long-term
商品
Innovations in polymer technology have had a significant impact on the advancement of novel drug delivery systems.
Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.
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