P208
PD 151,242
≥97%, powder
别名:
N-[N-[N-[(Hexahydro-1H-azepin-1-yl)carbonyl]-L-leucyl]-1-methyl-D-tryptophyl]-D-tyrosine
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选择尺寸
关于此项目
经验公式（希尔记法）:
C34H45N5O6
化学文摘社编号:
分子量:
619.75
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
InChI
1S/C34H45N5O6/c1-22(2)18-27(37-34(45)39-16-8-4-5-9-17-39)31(41)35-28(20-24-21-38(3)30-11-7-6-10-26(24)30)32(42)36-29(33(43)44)19-23-12-14-25(40)15-13-23/h6-7,10-15,21-22,27-29,40H,4-5,8-9,16-20H2,1-3H3,(H,35,41)(H,36,42)(H,37,45)(H,43,44)/t27-,28+,29+/m0/s1
SMILES string
CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc2cn(C)c3ccccc23)C(=O)N[C@H](Cc4ccc(O)cc4)C(O)=O
InChI key
JVILFANCFWZBFU-ZGIBFIJWSA-N
assay
≥97%
form
powder
color
white
storage temp.
−20°C
Biochem/physiol Actions
Selective ETA endothelin receptor antagonist.
Disclaimer
Photosensitive
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
C R Bacon et al.
British journal of pharmacology, 117(5), 986-992 (1996-03-01)
1. ETA and ETB-selective and non-selective ligands were used to define the endothelin receptors in the media (vascular smooth muscle layer) of human aorta and coronary artery. Saturation experiments with iodinated endothelin-1 (ET-1), endothelin-2 and sarafotoxin 6b (S6b) identified high
Clara Di Filippo et al.
Journal of hypertension, 21(4), 747-753 (2003-03-27)
Chronically administered ouabain increases the content of ouabain in several brain areas that are closely related to central cardiovascular regulation. However, the pattern of central changes induced by chronic infusion of ouabain is not completely understood. To investigate whether chronic
A P Davenport et al.
British journal of pharmacology, 111(1), 4-6 (1994-01-01)
Our aim was to synthesize a new endothelin ETA selective radioligand, [125I]-PD151242 and characterize the compound in human vascular tissue. Binding of [125I]-PD151242 to sections of human aorta was time-dependent and reached equilibrium after 120 min at 23 degrees C
Nadeshda Andreeva et al.
Folia microbiologica, 64(6), 867-873 (2019-04-03)
Inorganic polyphosphate is involved in architecture and functioning of yeast cell wall. The strain of Saccharomyces cerevisiae constitutively overexpressing acid phosphatase Pho5 was constructed for studying the Pho5 properties and its possible participation in polyphosphate metabolism. The parent strain was
C C Docherty et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 281(1), R261-R268 (2001-06-19)
At 110-111 days gestation, instrumented fetal sheep were administered saline or dexamethasone (2.2 microgram. kg(-1). h(-1) iv) for 48 h. Measurement of fetal blood pressure showed a greater increase in dexamethasone-treated (n = 6) compared with control (n = 5)
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