Biochem/physiol Actions
Potent hypotensive; induces salivation, intestinal contraction and vasodilation
Other Notes
Tachykinin originally isolated from the skin of the amphibian, Physalaemus fuscumaculatus; with structural homology to substance P
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Christy Rani R Grace et al.
Biopolymers, 96(3), 252-259 (2010-07-16)
Physalaemin (PHY), a non-mammalian tachykinin, binds selectively to neurokinin-1 (NK1) receptor with high affinity. Both the aqueous and lipid-induced conformations of PHY have been studied using two-dimensional nuclear magnetic resonance techniques. These data show that in water PHY prefers to
Anjali Dike et al.
Journal of structural biology, 156(3), 442-452 (2006-09-19)
Uperolein, a physalaemin-like endecapeptide, has been shown to be selective for Neurokinin 1 receptor. As a first step towards understanding the structure-activity relationship, we report the membrane-induced structure of Uperolein with the aid of circular dichroism and 2D (1)H NMR
Takahiko Shiina et al.
European journal of pharmacology, 628(1-3), 202-206 (2009-12-05)
We examined the effects of physalaemin, an agonist of tachykinin receptors, on mechanical responses in the rat esophagus to clarify possible regulatory roles of tachykinins in esophageal motility. Exogenous application of physalaemin caused tonic contractions in rat esophageal segments when
Daniel A Nelson et al.
Frontiers in bioscience : a journal and virtual library, 9, 2166-2176 (2004-09-09)
Mammalian tachykinins are traditionally viewed as neuropeptides. This review describes the mammalian tachykinins and evidence for expression of these peptides by non-neuronal cells. Tachykinin expression is defined as evidence for gene transcription, peptide production, or peptide secretion. Since the functions
S Lobasso et al.
Archives of physiology and biochemistry, 105(4), 329-336 (1998-08-26)
The effects of the non-mammalian tachykinin physalaemin were studied on the short circuit current (SCC) and on both influx (Ji) and outflux (Jo) of 36Cl- and 22Na+ across the isolated skin of Rana esculenta. Physalaemin, added to the internal bathing
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