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Merck
CN

P2178

Pro-Asp-Val-Asp-His-Val-Phe-Leu-Arg-Phe-NH2

≥97% (HPLC)

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关于此项目

经验公式(希尔记法):
C59H86N16O14
化学文摘社编号:
分子量:
1243.41
UNSPSC Code:
12352200
MDL number:
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SMILES string

CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]3CCCN3)C(C)C)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc4ccccc4)C(N)=O

assay

≥97% (HPLC)

storage temp.

−20°C

Biochem/physiol Actions

Cardioinhibitory; inhibits contraction of the oviduct visceral muscle, but potentiates contraction of the extensortibiae muscle

Other Notes

FMRF-amide-like neuropeptide originally isolated from locust (Schistocera gregaria)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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A B Lange et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(20), 9250-9253 (1995-09-26)
We describe a nonpeptide mimetic analog of an invertebrate peptide receptor. Benzethonium chloride (Bztc) is an agonist of the SchistoFLRFamide (PDVDHVFLRFamide) receptors found on locust oviducts. Bztc competitively displaces [125I-labeled Y1]SchistoFLRFamide binding to both high- and low-affinity receptors of membrane
A B Lange et al.
Peptides, 20(12), 1411-1418 (2000-03-04)
The external ventral protractor muscle of the VIIth abdominal segment, M234, is a skeletal muscle that possesses receptors that recognize a range of FMRFamide-related peptides and application of these peptides results in an increase in the amplitude of neurally evoked
L Schoofs et al.
Peptides, 14(3), 409-421 (1993-05-01)
An amidated decapeptide, exhibiting strong inhibitory activity of spontaneous visceral muscle movements, was isolated from 9000 brain-corpora cardiaca-corpora allata-subesophageal ganglion complexes of the migratory locust, Locusta migratoria. During the process of HPLC purifications, the biological activity of the fractions was
M Fusé et al.
Regulatory peptides, 77(1-3), 163-168 (1998-11-11)
We have previously shown differential expression of leucomyosuppressin (LMS) mRNA in apparent endocrine cells in the anterior region of midguts of the cockroach Diploptera punctata, using in situ hybridization. In contrast, other FMRFamide-related peptides, as revealed by immunohistochemistry, have been
S Robb et al.
Biochemical and biophysical research communications, 160(2), 850-856 (1989-04-28)
We have isolated a neuropeptide, related to the Phe-Met-Arg-Phe-NH2 family, from the thoracic nervous system of the locust, Schistocerca gregaria, using a purification system based on the radioimmunoassay of high pressure liquid chromatography fractions. The primary sequence of this locust

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