P222
Pandinotoxin-Kα
>99%, powder
登录查看公司和协议定价
选择尺寸
关于此项目
经验公式（希尔记法）:
C169H267N53O48S7
化学文摘社编号:
分子量:
4033.71
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.32
方案
>99%
表单
powder
颜色
off-white
储存温度
−20°C
Amino Acid Sequence
Thr-Ile-Ser-Cys-Thr-Asn-Pro-Lys-Gln-Cys-Tyr-Pro-His-Cys-Lys-Lys-αGlu-Thr-Gly-Tyr-Pro-Asn-Ala-Lys-Cys-Met-Asn-Arg-Lys-Cys-Lys-Cys-Phe-Gly-Arg
一般描述
Pandinotoxin (PiTX)-Kα is a 35 amino acid peptide isolated from venom of the scorpion Pandinus imperaton. PiTX-Kβ and PiTXγ are other two members of pandinotoxin group. All the three pandinotoxins have structures similar to another scorpion toxin charybdotoxin (ChTX). The structure of PiTXs contains a β-sheet at the C- terminal end with three cysteines which is linked to the central α-helix by two disulfide bridges (C17-C35 and C13-C33) and to an extended amino-terminal fragment by the third disulfide bridge (C7-C28).
生化/生理作用
Pandinotoxin (PiTX) –Kα along with PiTX-Kβ and PiTXγ plays a vital role in blocking voltage-gated K+ channels.
法律信息
Sold with the permission of University of Maryland.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
D R Matteson et al.
The Journal of physiology, 503 ( Pt 2), 285-301 (1997-11-05)
1. The ability of three structurally homologous scorpion toxins to block voltage-dependent K+ currents in rat dorsal root ganglion neurones was examined using the patch-clamp technique. 2. Neurones with a diameter > 35 microns had two identifiable components of macroscopic
R S Rogowski et al.
Molecular pharmacology, 50(5), 1167-1177 (1996-11-01)
Three 35-amino acid peptide K+ channel toxins (pandinotoxins) were purified from the venom of the scorpion Pandinus imperaton the toxins are designated pandinotoxin (PiTX)-K alpha, PiTX-K beta, and PiTX-K gamma. In an 86Rb tracer flux assay on rat brain synaptosomes
T C Tenenholz et al.
Biochemistry, 36(10), 2763-2771 (1997-03-11)
PiTX-K alpha, a 35-residue peptide recently isolated from the venom of Pandinus imperator, blocks the rapidly inactivating (A-type) K+ channel(s) in rat brain synaptosomes and the cloned Kv 1.2 potassium channel at very low toxin concentrations (6 nM and 32
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持