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P2371

Sigma-Aldrich

帕米膦酸钠 二钠盐 水合物

≥95% (NMR), solid

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别名:
3-氨基-1-羟基-1-膦酰基丙烷膦酸 二钠盐 水合物
经验公式（希尔记法）:
C3H9NO7P2Na2 · xH2O
CAS号:
57248-88-1
分子量:
279.03 (anhydrous basis)
EC 号:
260-647-1
MDL编号:
MFCD11045314
PubChem化学物质编号:
24724574
NACRES:
NA.77

质量水平

100

检测方案

≥95% (NMR)

形式

solid

颜色

white

mp

300 °C

溶解性

H2O: 28 mg/mL

创始人

Novartis

储存温度

2-8°C

SMILES字符串

O.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O

InChI

1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2

InChI key

TVQNUQCYOOJTMK-UHFFFAOYSA-L

生化/生理作用

帕米膦酸二钠具有阻断Wnt和β-catenin信号转导的能力，其可调节骨髓间充质干细胞（BMMSC）的成骨分化。它还可以减少胆红素受损的细胞凋亡，并帮助了来自人乳牙的干细胞发育成牙本质功能障碍。
骨吸收抑制剂；法呢基二磷酸合酶的抑制剂（IC50= 200 nM）。

特点和优势

该化合物由 Novartis 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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