P2371
帕米膦酸钠 二钠盐 水合物
≥95% (NMR), Bone resorption inhibitor, solid
别名:
3-氨基-1-羟基-1-膦酰基丙烷膦酸 二钠盐 水合物
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关于此项目
经验公式（希尔记法）:
C3H9NO7P2Na2 · xH2O
化学文摘社编号:
分子量:
279.03 (anhydrous basis)
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
帕米膦酸钠 二钠盐 水合物, ≥95% (NMR), solid
方案
≥95% (NMR)
表单
solid
颜色
white
mp
300 °C
溶解性
H2O: 28 mg/mL
创始人
Novartis
储存温度
2-8°C
SMILES字符串
O.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O
InChI
1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2
InChI key
TVQNUQCYOOJTMK-UHFFFAOYSA-L
生化/生理作用
帕米膦酸二钠具有阻断Wnt和β-catenin信号转导的能力，其可调节骨髓间充质干细胞（BMMSC）的成骨分化。它还可以减少胆红素受损的细胞凋亡，并帮助了来自人乳牙的干细胞发育成牙本质功能障碍。
骨吸收抑制剂；法呢基二磷酸合酶的抑制剂（IC50= 200 nM）。
特点和优势
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Pamidronate decreases bilirubin-impaired cell death and improves dentinogenic dysfunction of stem cells from human deciduous teeth
Yamaza H, et al.
Stem Cell Research & Therapy, 9(1), 303-303 (2018)
Amber L Watters et al.
Oral surgery, oral medicine, oral pathology and oral radiology, 115(2), 192-200 (2012-10-06)
We report long-term follow-up of patients with intravenous bisphosphonate-related osteonecrosis of the jaw (BRONJ). Medical and dental histories, including type and duration of bisphosphonate treatment and comorbidities, were analyzed and compared with clinical course of 109 patients with BRONJ at
Eitan Amir et al.
American journal of clinical oncology, 36(5), 436-442 (2012-07-12)
Despite substantial variability in individual risk of skeletal complications, patients with metastatic bone disease are treated with bisphosphonates at the same dose and dosing interval. This study assessed the feasibility of conducting a randomized trial of less frequent bisphosphonate administration
Pamidronate Disodium Leads to Bone Necrosis via Suppression of Wnt/beta-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells In Vitro
Xu Y, et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 75(10), 2135-2143 (2017)
Marcin Kos et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 71(6), 1010-1016 (2013-03-16)
Bacterial colonization of the denuded bone in bisphosphonate-related osteonecrosis of the jaw suggests that bisphosphonates increase bacterial adhesion and biofilm formation. This study evaluated the adhesion of gram-positive and gram-negative bacteria on hydroxyapatite coated with pamidronate, one of the most
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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