P2371
帕米膦酸钠 二钠盐 水合物
≥95% (NMR), Bone resorption inhibitor, solid
别名:
3-氨基-1-羟基-1-膦酰基丙烷膦酸 二钠盐 水合物
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关于此项目
经验公式（希尔记法）:
C3H9NO7P2Na2 · xH2O
化学文摘社编号:
分子量:
279.03 (anhydrous basis)
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
帕米膦酸钠 二钠盐 水合物, ≥95% (NMR), solid
方案
≥95% (NMR)
表单
solid
颜色
white
mp
300 °C
溶解性
H2O: 28 mg/mL
创始人
Novartis
储存温度
2-8°C
SMILES字符串
O.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O
InChI
1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2
InChI key
TVQNUQCYOOJTMK-UHFFFAOYSA-L
相关类别
生化/生理作用
帕米膦酸二钠具有阻断Wnt和β-catenin信号转导的能力，其可调节骨髓间充质干细胞（BMMSC）的成骨分化。它还可以减少胆红素受损的细胞凋亡，并帮助了来自人乳牙的干细胞发育成牙本质功能障碍。
骨吸收抑制剂；法呢基二磷酸合酶的抑制剂（IC50= 200 nM）。
特点和优势
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
George Bullock et al.
Materials (Basel, Switzerland), 13(9) (2020-05-07)
Medication-related osteonecrosis of the jaw (MRONJ) is a side effect of bisphosphonate therapy, characterised by exposed necrotic bone. The soft tissues of the oral mucosa no longer provide a protective barrier and MRONJ patients experience pain, infections and difficulties eating.
Evangelos Terpos et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(18), 2347-2357 (2013-05-22)
The aim of the International Myeloma Working Group was to develop practice recommendations for the management of multiple myeloma (MM) -related bone disease. An interdisciplinary panel of clinical experts on MM and myeloma bone disease developed recommendations based on published
John J Freiberger et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 70(7), 1573-1583 (2012-06-16)
This study tested hyperbaric oxygen (HBO) as an adjunct to surgery and antibiotics in the treatment of bisphosphonate-related osteonecrosis of the jaw (ONJ) and evaluated its effects on gingival healing, pain, and quality of life. The investigators implemented a randomized
Hong Li et al.
Cellular & molecular immunology, 10(2), 159-164 (2013-01-29)
γδ-T cells play an indispensable role in host defense against different viruses, including influenza A virus. However, whether these cells have cytotoxic activity against influenza virus-infected lung alveolar epithelial cells and subsequently contribute to virus clearance remains unknown. Using influenza
Janet E Brown et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 18(22), 6348-6355 (2012-09-07)
Survival is highly variable in women with bone metastases from breast cancer and prognostic factors are needed. We analyzed data from a phase III trial comparing zoledronic acid (ZOL) with pamidronate in patients with breast cancer and bone metastases to
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