P2371
帕米膦酸钠 二钠盐 水合物
≥95% (NMR), Bone resorption inhibitor, solid
别名:
3-氨基-1-羟基-1-膦酰基丙烷膦酸 二钠盐 水合物
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关于此项目
经验公式（希尔记法）:
C3H9NO7P2Na2 · xH2O
化学文摘社编号:
分子量:
279.03 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
260-647-1
MDL number:
产品名称
帕米膦酸钠 二钠盐 水合物, ≥95% (NMR), solid
InChI key
TVQNUQCYOOJTMK-UHFFFAOYSA-L
InChI
1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2
SMILES string
O.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O
assay
≥95% (NMR)
form
solid
color
white
mp
300 °C
solubility
H2O: 28 mg/mL
originator
Novartis
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
帕米膦酸二钠具有阻断Wnt和β-catenin信号转导的能力，其可调节骨髓间充质干细胞（BMMSC）的成骨分化。它还可以减少胆红素受损的细胞凋亡，并帮助了来自人乳牙的干细胞发育成牙本质功能障碍。
骨吸收抑制剂；法呢基二磷酸合酶的抑制剂（IC50= 200 nM）。
Features and Benefits
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Coralie Leblicq et al.
Pediatric blood & cancer, 60(5), 741-747 (2012-09-25)
Osteonecrosis (ON) is a severe complication of acute lymphoblastic leukemia (ALL) treatments. Recent studies suggest that bisphosphonates might reduce pain and loss of motor function in patients with ON. We assessed the effects of pamidronate compared to standard care in
Alexandre Loupy et al.
The Journal of clinical investigation, 122(9), 3355-3367 (2012-08-14)
Tight regulation of calcium levels is required for many critical biological functions. The Ca2+-sensing receptor (CaSR) expressed by parathyroid cells controls blood calcium concentration by regulating parathyroid hormone (PTH) secretion. However, CaSR is also expressed in other organs, such as
Uncomplicated vaginal delivery in two consecutive pregnancies carried to term in a woman with osteogenesis imperfecta type I and bisphosphonate treatment before conception.
Chih-Ping Chen et al.
Taiwanese journal of obstetrics & gynecology, 51(2), 305-307 (2012-07-17)
Marcin Kos et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 71(6), 1010-1016 (2013-03-16)
Bacterial colonization of the denuded bone in bisphosphonate-related osteonecrosis of the jaw suggests that bisphosphonates increase bacterial adhesion and biofilm formation. This study evaluated the adhesion of gram-positive and gram-negative bacteria on hydroxyapatite coated with pamidronate, one of the most
Ratna Chatterjee et al.
British journal of haematology, 159(4), 462-471 (2012-09-13)
This study aimed to evaluate bone remodelling disorders in thalassaemia by using pamidronate (PD) infusion with or without hormone replacement therapy (HRT) as a diagnostic-therapeutic tool. In this prospective study, 24 adult thalassaemia major (TM) and 10 thalassaemia intermedia (TI)
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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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