Merck
CN

P2443

Sigma-Aldrich

Pluronic® F-127

powder, BioReagent, suitable for cell culture

登录查看公司和协议定价

别名:
Non-ionic copolymer surfactant
线性分子式:
(C3H6O·C2H4O)x
CAS号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.75

描述

Non-ionic
contains 100ppm BHT

质量水平

产品线

BioReagent

形式

powder

分子量

~12600 g/mol

技术

cell culture | mammalian: suitable

CMC

950-1000 ppm (~25°C)

转变温度

cloud point >100 °C

HLB

18 - 23

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

一般描述

Pluronicpluronic® F-127,也称为泊洛沙姆 407,是一种无毒非离子共聚物。它含有以三嵌段结构排列的聚环氧乙烷-聚环氧丙烷,形成PEO-PPO-PEO对称。这种聚合物的表面活性剂特性来源于其两亲性,使它们能够与疏水表面和生物膜相互作用。

应用

Pluronic® F-127 已用于:

  • 作为肽到伤口部位的递送系统,以研究肽对小鼠伤口愈合的影响。
  • 作为 PDMS(聚二甲基硅氧烷)印章的表面涂层,使其具有水凝胶排斥性。
  • 制备用于测量神经活动的钙指示剂储备溶液。
  • 作为磷酸盐缓冲盐水 (PBS) 的成分,可降低非特异性细胞和蛋白质对基于 PDMS 的微流体装置的粘附。
  • 这种非离子共聚物表面活性剂适合作为消泡剂用于昆虫细胞培养应用。

生化/生理作用

Pluronic® F-127 是一种热可逆凝胶,由于其高热敏性、生物降解性和生物相容性而在不同行业中得到应用。这些特性使该聚合物适合用作多功能药物载体。Pluronic® F-127 通过提高药物的生物利用度和热稳定性来提高药物的治疗效果。此外,它还可以促进细胞附着和胶原蛋白形成,从而促进血管生成和组织再生。由于其功效,Pluronic F-127 已被用于间充质干细胞 (MSC) 的封装,以帮助血管水平低的组织再生,例如上皮组织、脂肪组织、软骨、肌腱和骨组织 。

法律信息

Pluronic is a registered trademark of BASF

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

为方便起见,与您过往购买产品相关的文件已保存在文档库中。

访问文档库

难以找到您所需的产品或批次号码?

在网站页面上,产品编号会附带包装尺寸/数量一起显示(例如:T1503-25G)。请确保 在“产品编号”字段中仅输入产品编号 (示例: T1503).

示例

T1503
货号
-
25G
包装规格/数量

其它示例:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

输入内容 1.000309185)

遇到问题?欢迎随时联系我们技术服务 寻求帮助

批号可以在产品标签上"批“ (Lot或Batch)字后面找到。

Aldrich 产品

  • 如果您查询到的批号为 TO09019TO 等,请输入去除前两位字母的批号:09019TO。

  • 如果您查询到的批号含有填充代码(例如05427ES-021),请输入去除填充代码-021的批号:05427ES。

  • 如果您查询到的批号含有填充代码(例如 STBB0728K9),请输入去除填充代码K9的批号:STBB0728。

未找到您寻找的产品?

部分情况下,可能未在线提供COA。如果搜索不到COA,可在线索取。

索取COA

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the molecular weight of Pluronic F-127, Product P2443?

    The average molecular weight is 12.6 kDa.

  4. Why has my solution of Pluronic F-127, Product P2443, gelled?

    Pluronic F-127 will form gels above 10 °C when used at concentrations of 18-50%. It will re-liquefy when cooled to below 10 °C. The gel should remain stable during autoclaving.

  5. What concentration of Pluronic F-127, Product P2443, should be used in cell culture?

    We test Pluronic F-127 in cell culture at 0.1 g/100 ml media (0.1%).  The concentration necessary for your cell application may vary.

  6. What can I use to dilute Pluronic F-127, Product P2443?

    The Pluronic F-127 is water soluble as stated on the Specification Sheet.

  7. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Environmentally responsive injectable materials
Bearat HH and Vernon BL
Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine, 263-297 (2011)
Dual-responsive (pH/temperature) Pluronic F-127 hydrogel drug delivery system for textile-based transdermal therapy
Chatterjee S, et al.
Scientific Reports, 9(1) (2019)
Connexin43 carboxyl-terminal peptides reduce scar progenitor and promote regenerative healing following skin wounding
Ghatnekar GS, et al.
Regenerative Medicine, 4(2), 205-223 (2009)
PLURONIC F127 and ITS applications
Salama AH
Pharmacology, 2, 1393- 1403 (2021)
Philippe Marmottant et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(41), 17271-17275 (2009-10-07)
Cell aggregates are a tool for in vitro studies of morphogenesis, cancer invasion, and tissue engineering. They respond to mechanical forces as a complex rather than simple liquid. To change an aggregate's shape, cells have to overcome energy barriers. If

商品

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

相关内容

Tissue engineering fabricates tissues cultures from scaffolds, living cells, and biologically active molecules by simulating the microenvironment of the body to repair or replace damaged tissue.

组织工程利用骨架、活细胞和生物活性分子通过模拟体内微环境来构建组织培养物,从而修复或替换受伤的组织。

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门