P2795
植物鞘氨醇盐酸盐 盐酸盐
别名:
4-羟基鞘氨醇, D-核糖-1,3,4-三羟基-2-十八胺, D-核糖-2-氨基十八-1,3,4-三醇, PHS
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经验公式（希尔记法）:
C18H39NO3 · HCl
化学文摘社编号:
分子量:
353.97
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
InChI
1S/C18H39NO3.ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20;/h16-18,20-22H,2-15,19H2,1H3;1H/t16-,17+,18-;/m0./s1
SMILES string
Cl.CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO
InChI key
GDKAAHDFPOWGQE-RXQQAGQTSA-N
form
powder
greener alternative product score
old score: 19
new score: 9
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greener alternative product characteristics
Less Hazardous Chemical Syntheses
Safer Solvents and Auxiliaries
Use of Renewable Feedstocks
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sustainability
Greener Alternative Product
greener alternative category
lipid type
sphingolipids
storage temp.
−20°C
Quality Level
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Biochem/physiol Actions
植物鞘氨醇是一种长链类鞘氨醇碱，广泛存在于酵母、植物和动物（包括哺乳动物）中。在酵母中，它可能通过激活 AGC 型蛋白激酶（Pkh1、Pkh2、Ypk1、Ypk2 和 Sch9）参与介导热应激反应。它在人类癌细胞系中具有促凋亡作用。PHS 直接或通过激活 p38MAPK 途径诱导 ΔΨm，并从线粒体释放细胞色素 c。这导致 caspase 9 激活，然后 caspase 3 激活和程序性细胞死亡。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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PloS one, 14(7), e0219252-e0219252 (2019-07-02)
To reach pre-elimination levels of tuberculosis (TB) incidence in the Netherlands, prevention of TB among immigrants through diagnosis and treatment of latent TB infection (LTBI) is needed. We studied the feasibility of a LTBI screening and treatment program among newly
Hyeseung Lee et al.
Molecular microbiology, 84(1), 130-146 (2012-02-22)
This study shows the importance of PDK1, TOR and PKC signalling pathways to the basal tolerance of Cryptococcus neoformans towards fluconazole, the widely used drug for treatment of cryptococcosis. Mutations in genes integral to these pathway resulted in hypersensitivity to
Marie-Thérèse El-Daher et al.
The EMBO journal, 34(17), 2255-2271 (2015-07-15)
Cleavage of mutant huntingtin (HTT) is an essential process in Huntington's disease (HD), an inherited neurodegenerative disorder. Cleavage generates N-ter fragments that contain the polyQ stretch and whose nuclear toxicity is well established. However, the functional defects induced by cleavage
P Sperling et al.
FEBS letters, 494(1-2), 90-94 (2001-04-12)
In the genome of Arabidopsis thaliana, two genes were identified encoding isoenzymes for C4-hydroxylation of long chain bases (LCB) in plant sphingolipids. Both predicted proteins consist of 258 amino acid residues (77% identity) which show sequence similarity to di-iron-binding enzymes
Karin Thevissen et al.
FEMS microbiology letters, 303(2), 163-168 (2009-12-25)
We demonstrated that a yeast deletion mutant in IPT1 and SKN1, encoding proteins involved in the biosynthesis of mannosyldiinositolphosphoryl ceramides, is characterized by increased autophagy and DNA fragmentation upon nitrogen (N) starvation as compared with the single deletion mutants or
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