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安全信息

P2928

Sigma-Aldrich

蕈青霉素

powder, ≥98% (HPLC)

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About This Item

经验公式(希尔记法):
C27H33NO4
CAS Number:
分子量:
435.56
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

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质量水平

方案

≥98% (HPLC)

表单

powder

颜色

faintly yellow

储存温度

2-8°C

SMILES字符串

CC(C)(O)C1OC2CCC3(C)C(O)(CCC4Cc5c([nH]c6ccccc56)C34C)C2=CC1=O

InChI

1S/C27H33NO4/c1-24(2,30)23-20(29)14-18-21(32-23)10-11-25(3)26(4)15(9-12-27(18,25)31)13-17-16-7-5-6-8-19(16)28-22(17)26/h5-8,14-15,21,23,28,30-31H,9-13H2,1-4H3/t15-,21-,23-,25+,26+,27+/m0/s1

InChI key

ACNHBCIZLNNLRS-UBGQALKQSA-N

一般描述

Paxilline is an indole diterpene metabolite produced by fungi. It has a functionalized pentacyclic core and is a template for the synthesis of a wide variety of derivatives.[1]

应用

Paxilline has been used to block large conductance calcium activated potassium channels (BKCa) in murine smooth muscle cells[2] and in myometrial cells of uterine samples.[3] Paxilline acts as an agonist and activates liver X receptor in atlantic salmon.[4]

生化/生理作用

Paxilline is a selective blocker of high-conductance Ca2+-activated (Maxi-K) potassium channels.[5] It also blocks big potassium (BK) channels.[6]

特点和优势

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

其他说明

Major toxin in Penicillium paxilli

象形图

Skull and crossbonesCorrosion

警示用语:

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

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