Name: 青霉震颤素 A
Brand: SIGMA

登录查看公司和协议定价

About This Item

经验公式（希尔记法）:

C₃₇H₄₄ClNO₆

CAS Number:

12627-35-9

分子量:

634.20

MDL编号:

MFCD00083465

UNSPSC代码:

12352200

PubChem化学物质编号:

24898385

NACRES:

NA.77

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

质量水平

200

方案

≥95% (HPLC and TLC)

表单

powder

储存温度

2-8°C

SMILES字符串

[H][C@]12CC[C@@]3(C)[C@@](O)(CC[C@@]4([H])[C@]5([H])OC(C)(C)[C@@]6([H])C[C@]7([H])C(=C)Cc8c(Cl)cc9[nH]c(c5c9c8[C@]67O)[C@]34C)[C@]1%10O[C@]%10([H])[C@@H](O)[C@H](O2)C(C)=C

InChI

1S/C37H44ClNO6/c1-15(2)28-27(40)31-37(45-31)23(43-28)9-10-33(6)34(7)18(8-11-35(33,37)41)29-25-24-21(39-30(25)34)14-20(38)17-12-16(3)19-13-22(32(4,5)44-29)36(19,42)26(17)24/h14,18-19,22-23,27-29,31,39-42H,1,3,8-13H2,2,4-7H3/t18-,19+,22+,23-,27-,28+,29-,31+,33+,34+,35-,36+,37-/m0/s1

InChI key

JDUWHZOLEDOQSR-JKPSMKLGSA-N

应用

Penitrem A has been used as Ca²⁺-Activated K⁺ (BK) channel blocker to study its effect on BK current in bag cell neurons.

生化/生理作用

Penitrem A intoxication causes ataxia, polypnea, and sustained tremors and may lead to seizures and death. Penitrem A affects the central and peripheral nervous system. It impairs the GABAergic neurotransmission in the cerebellum.

特点和优势

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.