P3076
Platelet-Derived Growth Factor-AA 人
PDGF-AA, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
别名:
PDGF−AA
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关于此项目
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥98% (SDS-PAGE and HPLC)
Form:
lyophilized powder
Mol wt:
28.5 kDa (containing 250 amino acid residues)
Impurities:
<1 EU/μg
biological source
human
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE and HPLC)
form
lyophilized powder
quality
endotoxin tested
mol wt
28.5 kDa (containing 250 amino acid residues)
packaging
pkg of 10 μg, pkg of 50 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
<1 EU/μg
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... PDGFRA(5154)
potency
≤1.0-3.0 ng/mL ED50
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General description
Platelet-derived growth factor (PDGF) is composed two polypeptide subunits of A and B chain. PDGF is produced by a number of cells including smooth muscle cells, endothelial cells and macrophages. The PDGF gene is highly conserved and is mapped to human chromosome 7p22.3. PDGF is structurally and functionally related to vascular endothelial growth factors.
Biochem/physiol Actions
Cell division and relocalization of pulmonary artery smooth muscle cells and fibroblasts is known to be triggered by platelet-derived growth factor (PDGF). Due to its proliferatory function, it is associated with fibroproliferative disorders such as atherosclerosis, pulmonary arterial hypertension and lung fibrosis. PDGF exists both in homo and heterodimeric forms and stimulates α and β-cell surface receptors. Vascular endothelial growth factor expression is regulated by PDGF-AA autocrine signalling and is known to promote tumor angiogenesis in vivo.
Physical form
Lyophilized from a sterile filtered buffered solution.
Analysis Note
The biological activity is measured by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells.
Other Notes
Homodimer of the A chain of human PDGF.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Clinical Findings Associated with a De Novo Partial Trisomy 10p11. 22p15. 3 and Monosomy 7p22. 3 Detected by Chromosomal Microarray Analysis.
Kohannim O, et al.
Case Reports in Genetics, 2011 (2011)
Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non?small cell lung carcinomas.
Shikada Y, et al.
Cancer Research, 65.16, 7241-7248 (2005)
Role of platelet-derived growth factors in physiology and medicine.
Andrae J, et al.
Genes & Development, 22.10, 1276-1312 (2008)
Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension.
Perros F, et al.
American Journal of Respiratory and Critical Care Medicine, 178.1, 81-88 (2008)
Neha Garg et al.
The EMBO journal, 32(21), 2819-2832 (2013-10-01)
The transcription factor Nanog plays a critical role in the self-renewal of embryonic stem cells as well as in neural stem cells (NSCs). microRNAs (miRNAs) are also involved in stemness regulation. However, the miRNA network downstream of Nanog is still
商品
Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.
血小板衍生生长因子是在哺乳动物血清中发现的主要有丝分裂原，在血栓形成过程中从血小板释放。
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