P3246
Pipamperone dihydrochloride
~99% (HPLC), dopamine receptor antagonist, powder
别名:
1′-[4-(4-Fluorophenyl)-4-oxobutyl]-[1,4′-bipiperidine]-4′-carboxamide dihydrochloride, R4050
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关于此项目
经验公式（希尔记法）:
C21H30N3O2F · 2HCl
化学文摘社编号:
分子量:
448.40
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
219-507-5
MDL number:
产品名称
Pipamperone dihydrochloride, ~99% (HPLC), powder
InChI
1S/C21H30FN3O2.2ClH/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25;;/h6-9H,1-5,10-16H2,(H2,23,27);2*1H
InChI key
BMXXSXQVMCXGJM-UHFFFAOYSA-N
SMILES string
Cl[H].Cl[H].NC(=O)C1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)N3CCCCC3
assay
~99% (HPLC)
form
powder
color
white
solubility
H2O: >2.0 mg/mL
originator
Johnson & Johnson
Quality Level
Application
Pipamperone dihydrochloride may be used:
- as an internal standard in liquid chromatography with coulometric detection
- as an antipsychotic drugs to test its interaction with human ether-a-go-go-related gene (hERG) channel
- as an internal standard to spike human colostrum samples for reversed phase liquid chromatography- ultraviolet (LC-UV) analysis
Biochem/physiol Actions
D2 dopamine receptor antagonist; 5-HT2 serotonin receptor antagonist; antipsychotic.
Pipamperone, a butyrophenone derivative is a pharmacological chaperone and is a membrane-permeable dopamine receptor D4 (DRD4) antagonist. The affinity of pipamperone is higher for DRD4 and 5-hydroxytryptamine 2A receptor (5-HT2A) in comparison with DRD2. It may be useful therapeutic in treating behavioral disorders and psychomotor agitation symptoms.
Features and Benefits
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
A Van Eeckhaut et al.
Journal of clinical pharmacy and therapeutics, 42(3), 306-310 (2017-03-16)
In our university hospital (UZBrussel), one of the options to control post-operative pain after a Caesarean section under general anaesthesia is to administer piritramide by patient-controlled intravenous analgesia (PCIA). As no information is available about the possible transfer of this
Kathelijne Peremans et al.
Nuclear medicine communications, 29(8), 724-729 (2008-08-30)
To conduct a cost-efficient pilot study on the effect of low-dose pipamperone on the serotonin-2A receptor binding in a large animal model with conventional single-photon emission tomography modalities. Three healthy drug-naive female Beagle dogs were scanned before and after administration
Eva Saar et al.
Journal of mass spectrometry : JMS, 45(8), 915-925 (2010-07-22)
Over the last decade, the prescription rates of antipsychotic (AP) drugs have increased worldwide. Studies have shown that the risk of sudden cardiac death is threefold higher among patients treated with APs. To investigate the presence of APs in postmortem
P A Janssen et al.
Arzneimittel-Forschung, 44(3), 269-277 (1994-03-01)
In 1965 the first study of this series reported different effects of neuroleptics in rats, supporting clinical differences. At the one end, haloperidol presented as a potent and specific antagonist of the psychostimulants amphetamine and apomorphine. Haloperidol-like neuroleptics have marked
The treatment of autism with pipamperone: A case report
Petrosino B, et al.
European Psychiatry : The Journal of the Association of European Psychiatrists, 33, S682-S682 (2016)
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