跳转至内容
Merck
CN

P3326

Sigma-Aldrich

Platelet-Derived Growth Factor-AB 人

≥97% (SDS-PAGE and N-terminal analysis), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

别名:

PDGF-AB

登录查看公司和协议定价

选择尺寸

关于此项目

MDL编号:
MFCD00213024
UNSPSC代码:
12352202
NACRES:
NA.77

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

Platelet-Derived Growth Factor-AB 人, PDGF-AB, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

生物来源

human

质量水平

200

重组

expressed in E. coli

方案

≥97% (SDS-PAGE and N-terminal analysis)

表单

lyophilized powder

效能

10-100 ng/mL ED50/EC50

质量

endotoxin tested

分子量

27-31 kDa

包装

pkg of 10 μg
pkg of 50 μg

储存条件

avoid repeated freeze/thaw cycles

技术

cell culture | mammalian: suitable

杂质

≤1 EU/μg

UniProt登记号

P04085, P01127

储存温度

−20°C

基因信息

human ... PDGFA(5154), PDGFB(5155)

正在寻找类似产品? 访问 产品对比指南

相关类别

一般描述

Platelet-Derived Growth Factor (PDGF) is a cationic polypeptide and a constituent of α-granules. PDGF is composed of chain A and B linked together by a disulphide bridge. PDGF heterodimers occurs as PDGF-AB and homodimers exists as FDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD). The PDGFB gene is localized to pericytes in the brain and is mapped to human chromosome 7p22.3.

应用

Platelet-Derived Growth Factor-AB human has been used in luciferase reporter assay.

生化/生理作用

Cellular actions of platelet-derived growth factor (PDGF) include chemoattraction and activation of neutrophils, monocytes, and fibroblasts. PDGF appears to play a crucial role in the cellular response to tissue injury and is critically involved in the pathological progression of atherosclerosis.
PDGF stimulates fibroblast proliferation and extracellular matrix production in order to facilitate tissue repair. PDGF-AB isomer is found to be associated with angiogenesis and proliferation. Loss of PDGFB gene function induces microvascular calcification due to age-dependent phenotypical changes.

外形

Lyophilized from a 0.2 μm filtered solution in 40% acetonitrile and 0.1% trifluoroacetic acid.

分析说明

The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in quiescent NR6R-3T3 fibroblasts.

其他说明

Heterodimer of the A and B chains of PDGF disulfide linked.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000259465
0000259465
0000254608
0000254608
SLCL0612

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Increased levels of platelet-derived growth factor in vitreous fluid of patients with proliferative diabetic retinopathy.
Freyberger H, et al.
Experimental and Clinical Endocrinology & Diabetes, 108.02, 106-109 (2000)
Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts.
Antoniades HN, et al.
Proceedings of the National Academy of Sciences of the USA, 88.2 , 565-569 (1991)
Deconstructing Fahr's disease/syndrome of brain calcification in the era of new genes
Batla A, et al.
Parkinsonism & Related Disorders, 37, 1-10 (2017)
Intraglomerular expressions of IL-1a and platelet-derived growth factor (PDGF-B) mRNA in experimental immune complex-mediated glomerulonephritis.
Akai Y, et al.
Clinical and Experimental Immunology, 95.1, 29-34 (1994)
Identification of nerve growth factor-responsive element of the TCL1 promoter as a novel negative regulatory element.
Hiromura M, et al.
The Journal of Biological Chemistry, 281.38, 27753-27764 (2006)
查看所有相关文献

商品

Platelet Derived Growth Factors (PDGF)

Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.

血小板衍生生长因子(PDGF)

血小板衍生生长因子是在哺乳动物血清中发现的主要有丝分裂原，在血栓形成过程中从血小板释放。

相关内容

Data Sheet - P3326

Instructions

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持