五氟利多

Name: 五氟利多
Brand: SIGMA

≥97% (HPLC), powder

别名:

1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol, R16341

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所有图片(1)

About This Item

经验公式（希尔记法）:

C₂₈H₂₇ClF₅NO

CAS Number:

26864-56-2

分子量:

523.97

EC 号:

248-074-5

MDL编号:

MFCD00866714

UNSPSC代码:

12352200

PubChem化学物质编号:

329820171

NACRES:

NA.77

质量水平

100

方案

≥97% (HPLC)

表单

powder

颜色

white

溶解性

DMSO: >20 mg/mL
H₂O: insoluble

创始人

Johnson & Johnson

储存温度

2-8°C

SMILES字符串

OC1(CCN(CCCC(c2ccc(F)cc2)c3ccc(F)cc3)CC1)c4ccc(Cl)c(c4)C(F)(F)F

InChI

1S/C28H27ClF5NO/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24,36H,1-2,13-17H2

InChI key

MDLAAYDRRZXJIF-UHFFFAOYSA-N

应用

Penfluridol has been used as an antipsychotic agent:

to study its antimetastatic effect on triple-negative breast cancer cells
to study its effects on the growth of glioblastoma cell lines,
to study its effects on the vascular endothelial growth factor (VEGF)-induced angiogenesis in human umbilical vein endothelial cells (HUVECs)

生化/生理作用

Penfluridol is studied in the treatment of schizophrenia, Tourette syndrome and acute psychosis. It also exhibits anticancer activity.

T-type Ca²⁺channel blocker; antipsychotic

特点和优势

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.