P3371
五氟利多
≥97% (HPLC), powder
别名:
1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol, R16341
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关于此项目
经验公式（希尔记法）:
C28H27ClF5NO
化学文摘社编号:
分子量:
523.97
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
248-074-5
MDL number:
产品名称
五氟利多, ≥97% (HPLC), powder
InChI
1S/C28H27ClF5NO/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24,36H,1-2,13-17H2
InChI key
MDLAAYDRRZXJIF-UHFFFAOYSA-N
SMILES string
OC1(CCN(CCCC(c2ccc(F)cc2)c3ccc(F)cc3)CC1)c4ccc(Cl)c(c4)C(F)(F)F
assay
≥97% (HPLC)
form
powder
color
white
solubility
DMSO: >20 mg/mL
H2O: insoluble
originator
Johnson & Johnson
storage temp.
2-8°C
Quality Level
相关类别
Application
Penfluridol has been used as an antipsychotic agent:
- to study its antimetastatic effect on triple-negative breast cancer cells
- to study its effects on the growth of glioblastoma cell lines,
- to study its effects on the vascular endothelial growth factor (VEGF)-induced angiogenesis in human umbilical vein endothelial cells (HUVECs)
Biochem/physiol Actions
Penfluridol is studied in the treatment of schizophrenia, Tourette syndrome and acute psychosis. It also exhibits anticancer activity.
T-type Ca2+ channel blocker; antipsychotic
Features and Benefits
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
W Peters et al.
Annals of tropical medicine and parasitology, 85(1), 5-10 (1991-02-01)
Multiple drug resistance in Plasmodium falciparum is already showing evidence of extending to mefloquine, which at present is one of the few alternative antimalarials for the prevention or treatment of infection with such parasites. Neither verapamil nor cyproheptadine, which reverse
Orna Diav-Citrin et al.
The Journal of clinical psychiatry, 66(3), 317-322 (2005-03-16)
To assess the safety of the butyrophenone neuroleptics haloperidol and penfluridol in pregnancy. The rate of major anomalies was compared between a cohort of pregnant women counseled for gestational exposure to haloperidol or penfluridol and a control group counseled for
J J Enyeart et al.
The Journal of biological chemistry, 265(27), 16373-16379 (1990-09-25)
The effects of diphenylbutylpiperidine (DPBP) antipsychotics on Ca2+ currents and prolactin (PRL) synthesis were studied in rat pituitary growth hormone (GH) cell lines (GH3 and GH4C1). In whole-cell patch-clamp experiments, DPBPs including fluspirilene, penfluridol, and pimozide at concentrations ranging from
J C Gomora et al.
The Journal of pharmacology and experimental therapeutics, 290(1), 266-275 (1999-06-25)
Bovine adrenal zona fasciculata cells express a novel K+ current (IAC) that sets the resting potential while it couples adrenocorticotropin and angiotensin II receptors to membrane depolarization and cortisol secretion. IAC is distinctive among K+ channels both in its activation
B Spivak et al.
International clinical psychopharmacology, 11(3), 207-209 (1996-09-01)
Neuroleptic malignant syndrome (NMS) is a severe side-effect of neuroleptic treatment. It is usually related to hypodopaminergic activity. A young schizophrenic patient who developed a typical episode of NMS during abrupt withdrawal of long-acting neuroleptic combined with anticholinergic treatment is
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