P3415
3-（2-吡啶二硫）丙酸 N -羟基琥珀酰亚胺酯
≥95%, powder
别名:
N-琥珀酰亚胺-3-(2-吡啶二硫代)丙酸酯, SPDP
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经验公式（希尔记法）:
C12H12N2O4S2
化学文摘社编号:
分子量:
312.36
UNSPSC Code:
12352106
NACRES:
NC.07
PubChem Substance ID:
EC Number:
269-034-3
Beilstein/REAXYS Number:
1548137
MDL number:
Assay:
≥95%
Form:
powder
InChI key
JWDFQMWEFLOOED-UHFFFAOYSA-N
InChI
1S/C12H12N2O4S2/c15-10-4-5-11(16)14(10)18-12(17)6-8-19-20-9-3-1-2-7-13-9/h1-3,7H,4-6,8H2
SMILES string
O=C(CCSSC1=NC=CC=C1)ON2C(CCC2=O)=O
assay
≥95%
form
powder
reaction suitability
reagent type: cross-linking reagent
mp
84-86 °C (lit.)
solubility
acetone: 50 mg/mL, DMF: soluble
functional group
NHS ester
storage temp.
−20°C
Quality Level
General description
3-(2-吡啶基二硫代)丙酸 N-羟基琥珀酰亚胺酯（SPDP）是具有胺和巯基反应性的异源双功能交联剂。通常先在pH 7.5（6.5-8.5）的缓冲条件下通过酰胺键与含有伯胺的分子偶联。在pH 8.0（7.5-8.5）的缓冲条件下通过硫醇-二硫化物交换反应，与含有游离巯基的分子特异性二次偶联。此外，该试剂还可在初次偶联和还原接头后用作受保护的硫醇化试剂。它包含四个原子连接器。
Application
3-（2-吡啶基二硫代）丙酸N-羟基琥珀酰亚胺酯（SPDP）可用于制备酶免疫缀合物和半抗原载体分子偶联物。它已用于抗体缀合和作为蛋白质交联剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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