P3415
3-（2-吡啶二硫）丙酸 N -羟基琥珀酰亚胺酯
≥95%, powder
别名:
N-琥珀酰亚胺-3-(2-吡啶二硫代)丙酸酯, SPDP
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关于此项目
经验公式（希尔记法）:
C12H12N2O4S2
化学文摘社编号:
分子量:
312.36
Beilstein:
1548137
EC 号:
MDL编号:
UNSPSC代码:
12352106
PubChem化学物质编号:
NACRES:
NC.07
质量水平
方案
≥95%
表单
powder
反应适用性
reagent type: cross-linking reagent
mp
84-86 °C (lit.)
溶解性
acetone: 50 mg/mL
DMF: soluble
官能团
NHS ester
储存温度
−20°C
SMILES字符串
O=C(CCSSC1=NC=CC=C1)ON2C(CCC2=O)=O
InChI
1S/C12H12N2O4S2/c15-10-4-5-11(16)14(10)18-12(17)6-8-19-20-9-3-1-2-7-13-9/h1-3,7H,4-6,8H2
InChI key
JWDFQMWEFLOOED-UHFFFAOYSA-N
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一般描述
3-(2-吡啶基二硫代)丙酸 N-羟基琥珀酰亚胺酯（SPDP）是具有胺和巯基反应性的异源双功能交联剂。通常先在pH 7.5（6.5-8.5）的缓冲条件下通过酰胺键与含有伯胺的分子偶联。在pH 8.0（7.5-8.5）的缓冲条件下通过硫醇-二硫化物交换反应，与含有游离巯基的分子特异性二次偶联。此外，该试剂还可在初次偶联和还原接头后用作受保护的硫醇化试剂。它包含四个原子连接器。
应用
3-（2-吡啶基二硫代）丙酸N-羟基琥珀酰亚胺酯（SPDP）可用于制备酶免疫缀合物和半抗原载体分子偶联物。它已用于抗体缀合和作为蛋白质交联剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Ping Wang et al.
Scientific reports, 10(1), 5302-5302 (2020-03-27)
Aberrant expression of miRNAs in pancreatic islets is closely related to the development of type 1 diabetes (T1D). The aim of this study was to identify key miRNAs dysregulated in pancreatic islets during T1D progression and to develop a theranostic
Zdravka Medarova et al.
Scientific reports, 10(1), 1970-1970 (2020-02-08)
Chemotherapy, a major cancer treatment approach, suffers seriously from multidrug resistance (MDR), generally caused by innate DNA repair proteins that reverse the DNA modification by anti-cancer therapeutics or trans-membrane efflux proteins that pump anti-cancer therapeutics out of the cytosol. This
Peter R Berthold et al.
Bioconjugate chemistry, 21(10), 1933-1938 (2010-09-30)
Peptide nucleic acid (PNA) is potentially an attractive antisense and antigene agent for which more efficient cellular delivery systems are still warranted. The cationic polymer polyethylenimine (PEI) is commonly used for cellular transfection of DNA and RNA complexes, but is
Anita C Thomas et al.
Journal of controlled release : official journal of the Controlled Release Society, 100(3), 357-377 (2004-11-30)
There is an urgent need to treat restenosis, a major complication of the treatment of arteries blocked by atherosclerotic plaque, using local delivery techniques. We observed that cross-linked fibrin (XLF) is deposited at the site of surgical injury of arteries.
Shima Gholizadeh et al.
International journal of pharmaceutics, 548(2), 747-758 (2017-10-19)
Dactolisib (NVP-BEZ235, also referred to as: 'BEZ235' or 'BEZ') is a dual mTOR/PI3K inhibitor that is of potential interest in the treatment of inflammatory disorders. This work focuses on formulation of BEZ-loaded polymeric nanoparticles composed of a blend of poly(D,L-lactide-co-glycolide)
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